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EPHB2 — IL4

Text-mined interactions from Literome

Soon et al., Mol Cell Biol 1999 : IL-4 stimulation of the IGF-IR transfectants resulted in enhanced tyrosine phosphorylation of SHC, Erk2 , and signal transducer and activator of transcription 6 ( STAT6 ) proteins
Valledor et al., J Biol Chem 2000 : Granulocyte/macrophage colony stimulating factor, interleukin 3, and TPA, all of which induced macrophage proliferation, also induced ERK activity, which was maximal at 5 min poststimulation
Hirst et al., Am J Respir Crit Care Med 2002 : Activation of IL-4Ralpha by IL-13 or IL-4 induced signal transducer and activation of transcription-6 ( STAT6 ), p42/ p44 ERK , p38, and to a lesser extent, SAPK/JNK mitogen activated protein kinase phosphorylation
Nagano et al., Int Immunol 2002 : Taken together, these results suggest that both ERK and p38 ( MAPK ) pathways are involved in LPS induced COX-2 expression and PGE ( 2 ) production in neutrophils, and IL-10 and IL-4 inhibit neutrophil prostanoid synthesis by down regulating the activation of p38 ( MAPK )
Jorritsma et al., J Immunol 2003 (MAP Kinase Signaling System) : In this study, we show that Erk plays a critical role in IL-4 expression during TCR induced Th differentiation of naive CD4 ( + ) T cells ... However, reduction of Erk activity led to a dramatic increase in IL-4 production and Th2 generation ... In addition, these data suggest that TCR induced Erk activation is involved in the regulation of IL-4 expression by altering the composition of the AP-1 complex and its subsequent DNA binding activity
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : ERK or JNKinhibitors partially inhibited IL-4 and IL-10 secretion, while PKC or p38 inhibitors had no significant effects on IL-4 or IL-10 secretion
Maggi et al., J Biol Chem 2003 (Cardiovirus Infections...) : ERK activation is required for double stranded RNA- and virus induced interleukin-1 expression by macrophages
MacGillivray et al., J Biol Chem 2003 (MAP Kinase Signaling System) : The protein tyrosine phosphatase SHP-2 regulates interleukin-1 induced ERK activation in fibroblasts
Deszo et al., Cell Signal 2004 : PMA+IL-4 treatment also induced a synergistic enhancement of ERK1/2 activation when compared to the effects of PMA and IL-4 alone
Chang et al., J Biol Chem 2004 (Inflammation...) : The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK activation
Wang et al., J Biol Chem 2005 : SHP-2 modulates interleukin-1 induced Ca2+ flux and ERK activation via phosphorylation of phospholipase Cgamma1
Miranda et al., Leuk Res 2005 (MAP Kinase Signaling System) : Additionally, interleukin-3 , which inhibits G-CSF induced differentiation of 32 Dc l3 cells, also inhibited the ability of G-CSF to stimulate prolonged MEK/ERK activation
Cui et al., Biochem Biophys Res Commun 2006 (Carcinoma, Non-Small-Cell Lung...) : IL-4 inhibited IL-1beta stimulated ERK phosphorylation, which may mediate the inhibition of IL-1beta induced COX-2 by IL-4
Ip et al., Clin Exp Immunol 2006 (MAP Kinase Signaling System) : Inhibition of p38 MAPK, ERK and JAK-2 activities by pretreating the cells with their corresponding inhibitors SB203580, PD98059 and AG490, respectively, significantly suppressed IL-4- and IL-13 induced MCP-1 production in BEAS-2B cells
Jang et al., Cell Immunol 2006 : In fact, IL-4 induced specific activation of NF-kappaB, Akt, and Erk in Jurkat T cells and partially rescued these cells from dexamethasone induced apoptosis
So et al., Mol Immunol 2007 (MAP Kinase Signaling System) : In cytokine producing Jurkat T cells, we have found that IL-4 induces activation of Erk and Akt, and the IL-4 induced STAT6 activity is suppressed by inhibitors of Erk and PI3K ... The Ras induced increase of both STAT6 activity and IL-4 mRNA level was effectively blocked by a Mek/Erk inhibitor, suggesting that Ras/Erk pathway positively regulates STAT6 activity and IL-4 transcription
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Calvo et al., Blood 2008 (Lymphoma, Follicular...) : IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma
Chiu et al., Pediatr Neonatol 2008 : Osthol did not suppress IL-4 induced p38, ERK or JNK expression
Woolson et al., Cell Signal 2009 : Here we demonstrate that elevation of cyclic AMP ( cAMP ) levels in human umbilical vein endothelial cells ( HUVECs ) specifically attenuates ERK1,2 activation in response to either leptin or a soluble interleukin IL-6 receptor-alpha/IL-6 ( sIL-6R alpha/IL-6 ) trans signalling complex but not protein kinase C activator phorbol 12-myristate 13-acetate
Saraiva et al., Immunity 2009 : Interleukin-10 production by Th1 cells requires interleukin-12 induced STAT4 transcription factor and ERK MAP kinase activation by high antigen dose
Cuong et al., Life Sci 2009 (Inflammation...) : Pre-treatment with C-K significantly inhibited zymosan mediated secretion of tumor necrosis factor-alpha, interleukin (IL)-6 , and IL-12 p40, and the activation of ERK1/2 and p38
Leonardi et al., Clin Exp Allergy 2011 (Conjunctivitis, Allergic) : In addition, histamine, IL-4 and TNF-a increased JNK and ERK1/2 expression
Cho et al., Mol Immunol 2011 : However, IL-4 did not affect LPS induced phosphorylation of ERK and p38
Khan et al., J Biol Chem 2012 : Induction of IL-4 in CD4 ( + ) T cells by Thp5 is independent of the transcription factor STAT6 but dependent on ERK1/2 signaling
Rafei et al., Blood 2013 (Atrophy...) : IL-4 activates STAT6 and ERK and supports the differentiation of CD8 ( int ) PD-L1 ( hi ) CD44 ( hi ) EOMES ( + ) innate CD8 T cells
Hosokawa et al., Cell Physiol Biochem 2013 : Western blot analysis revealed that EGCG treatment prevented IL-1ß/IL-4 or TNF-a/IL-4 induced ERK and JNK activation in HGFs. Conclusions : These data provide that CCL11 production in HGFs could be associated with Th2 cells infiltration in periodontal lesions
Lo et al., J Biol Chem 1998 : Requirements of focal adhesions and calcium fluxes for interleukin-1 induced ERK kinase activation and c-fos expression in fibroblasts
Egerton et al., Int Immunol 1998 : However, the production of IL-3 and IL-4 was only partially dependent upon ERK activation, whereas IL-5, IL-10, IFN-gamma and GM-CSF production was severely affected by diminished ERK activation
Niiro et al., Biochem Biophys Res Commun 1998 : Interestingly, LPS induced phosphorylation and activation of ERK2 was significantly inhibited by IL-4 and IL-10, while that of p38 MAPK was inhibited by IL-10, but not IL-4
Chan et al., Biochem Biophys Res Commun 1998 : Our results show that IL-4 modestly inhibited JNK/SAPK and ERK activation by TNF-alpha