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CCR5 — MDM1
Text-mined interactions from Literome
Atemezem et al., Biochem J 2001
:
Therefore both AGP glycans and MDM
CCR5 are
involved in the binding of AGP to
MDM. This suggests that the inhibitory effect of AGP on the infection of human primary macrophages by R5 HIV-1 may be related to specific binding of AGP to a macrophage membrane lectin or lectin-like component and to CCR5
Perez-Bercoff et al., J Virol 2003
:
Although
MDM activation by immobilized IgG
induced high levels of macrophage derived chemokine secretion as well as a sustained down-regulation of CD4 and a transient decrease in
CCR5 expression, these factors did not appear to play a major role in the suppression of HIV-1 replication