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BRCA1 — CDK2
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Bind Interaction:
BRCA1
—
CDK2
Ruffner et al., Mol Cell Biol 1999*, Wang et al., Oncogene 1997
-
IRef Bind_translation Interaction:
BRCA1
—
CDK2
(affinity chromatography technology)
Wang et al., Oncogene 1997
-
IRef Biogrid Interaction:
BRCA1
—
CDK2
(physical association, affinity chromatography technology)
Ruffner et al., Mol Cell Biol 1999*
-
IRef Biogrid Interaction:
BRCA1
—
CDK2
(direct interaction, pull down)
Ruffner et al., Mol Cell Biol 1999*
-
IRef Biogrid Interaction:
BRCA1
—
CDK2
(direct interaction, pull down)
Wang et al., Oncogene 1997
-
IRef Biogrid Interaction:
BRCA1
—
CDK2
(direct interaction, enzymatic study)
Chen et al., Cancer Res 1996*
-
IRef Hprd Interaction:
Complex of 19 proteins
(in vivo)
Ruffner et al., Mol Cell Biol 1999*, Wang et al., Oncogene 1997
-
IRef Hprd Interaction:
BRCA1
—
CDK2
(in vitro)
Ruffner et al., Mol Cell Biol 1999*
-
IRef Hprd Interaction:
BRCA1
—
CDK2
(in vivo)
Ruffner et al., Mol Cell Biol 1999*
-
IRef Ophid Interaction:
BRCA1
—
CDK2
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Ouchi et al., Proc Natl Acad Sci U S A 2000
:
After IFN-gamma treatment, induction of the
cyclin dependent kinase inhibitor, p21WAF1, was synergistically
activated by
BRCA1 , whereas the IRF-1 gene was unaffected
Hayami et al., Cancer Res 2005
(Breast Neoplasms...) :
Here we show that the ubiquitin ligase activity of
BRCA1-BARD1 is
down-regulated by
CDK2