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BDNF — MED6

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Ying et al., J Neurosci 2002 : Brain derived neurotrophic factor induces long-term potentiation in intact adult hippocampus : requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
Bramham et al., Prog Neurobiol 2005 : Recent experiments suggest that BDNF activates synaptic consolidation through transcription and rapid dendritic trafficking of mRNA encoded by the immediate early gene, Arc
Wang et al., Neurosci Lett 2006 : Consistent with the literature, Arc , an indicator of synaptic plasticity, was induced by BDNF ( 25 ng/ml ) in both dose- and time dependent manners
Echeverria et al., Curr Alzheimer Res 2007 : Using a model of synaptic plasticity in which BDNF increases Arc expression in cultured cortical neurons, we have found that an oligomeric form of Abeta strongly inhibits the BDNF induced increase of Arc expression
Zheng et al., J Neurosci Res 2009 : In contrast, chelating intracellular calcium ( [ Ca ( 2+ ) ] ( i ) ) by BAPTA-AM abolished BDNF mediated Arc up-regulation
Chen et al., J Neurosci Res 2009 : In this study, BDNF treatment alone induced the activation of the phosphatidylinositol 3-kinase-Akt-mammlian target of rapamycin ( PI3K-Akt-mTOR ) signaling pathway, the phosphorylation of eukaryotic initiation factor 4E binding protein ( 4EBP1 ) and p70 ribosomal S6 kinase (p70S6K), the dephosphorylation of eukaryotic elongation factor 2 ( eEF2 ), and the expression of Arc
Tong et al., J Neurosci 2012 : Using rat organotypic hippocampal cultures, we found that IL-1ß suppressed BDNF dependent regulation of Arc and phosphorylation of cofilin and cAMP response element binding protein ( CREB ), a transcription factor regulating Arc expression
Tikhonova et al., Chin J Physiol 2012 : BDNF also augmented mRNA levels of Arc gene encoding Arc ( Activity regulated cytoskeleton associated ) protein involved in BDNF induced processes of neuronal and synaptic plasticity in hippocampus and prefrontal cortex