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IRF3 — PTPN11

Text-mined interactions from Literome

Donelan et al., J Virol 2004 : Expression of the full-length B/NS1 protein ( 281 amino acids ), as well as either its N-terminal RNA binding domain ( amino acids 1 to 93 ) or C-terminal domain ( amino acids 94 to 281 ), in the absence of any other influenza B virus proteins resulted in the inhibition of IRF-3 nuclear translocation and IFN-beta promoter activation
Mibayashi et al., J Virol 2007 : Our results indicate that, in addition to sequestering dsRNA, the NS1 of influenza A virus binds to RIG-I and inhibits downstream activation of IRF-3 , preventing the transcriptional induction of IFN-beta