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IL13 — MMP13

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP13 → IL13 (decreases) Tardif et al., Arthritis Rheum 1999*
  Evidence: Treatment of Osteoarthritic (OA) chondrocytes with IL-1beta highly enhanced collagenase 3 production in L chondrocytes, but had a lesser effect on H chondrocytes (L chondrocytes had low collagenase 3 basal levels and a high IL-1beta inducibility while H chondrocytes had high basal levels and low IL-1beta inducibility). IL-13 reduced the level of IL-1beta stimulated collagenase 3 in L chondrocytes.

Text-mined interactions from Literome

Meisser et al., Mol Hum Reprod 1999 : The aim of this study was to determine the effects of tumour necrosis factor alpha (TNF), interleukin-1 alpha (IL-1alpha), macrophage colony stimulating factor ( MCSF ) and transforming growth factor beta ( TGFbeta ) on the secretion of matrix metalloproteinases ( MMP ) , human chorionic gonadotrophin ( HCG ) and fetal fibronectin ( fFN ) by purified first trimester cytotrophoblastic cells (CTB) in vitro
Cleaver et al., Ann Rheum Dis 2001 : Northern blot analyses were performed to determine the effects of IL13 on the induction of matrix metalloproteinase-1 (MMP-1), MMP-3, MMP-13 , and TIMP-1 gene expression ... Northern blot analysis showed that IL13 down regulated MMP-3 and MMP-13 levels but up regulated MMP-1 and TIMP-1 gene expression in bovine nasal chondrocytes at 24 hours
Wahlgren et al., J Pathol 2001 (Bone Diseases...) : Phorbol-12-myristate-13-acetate, interleukin-6 , and tumour necrosis factor-alpha and heparin with the tumour promoter or cytokines potently enhanced ( up to nine-fold ) MMP-8 and -13 expression by the RPMI 8226 myeloma cell line, as evidenced by western blotting and semi-quantitative reverse transcriptase-polymerase chain reaction
Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Sun et al., Connect Tissue Res 2003 (Arthritis, Rheumatoid) : Furthermore, the induction of the MMP expression and activities by interleukin-1 was suppressed by the oscillatory shear
Ma et al., J Immunol 2004 (Inflammation) : C10/CCL6 neutralization also decreased the ability of IL-13 to stimulate the production of monocyte chemoattractant protein-1, macrophage inflammatory protein-1alpha, MMP-2 , MMP-9, and cathepsins-K, -L, and -S and the ability of IL-13 to inhibit alpha1-antitrypsin
Im et al., J Biol Chem 2007 : bFGF stimulation of MMP-13 was mediated at the transcriptional level and, at least in part, by stimulation of interleukin-1 production
Ahmad et al., Cell Signal 2007 (MAP Kinase Signaling System) : MyD88, IRAK1 and TRAF6 knockdown in human chondrocytes inhibits interleukin-1 induced matrix metalloproteinase-13 gene expression and promoter activity by impairing MAP kinase activation
Madala et al., J Immunol 2010 (Fibrosis...) : Instead, we observed marked increases in MMP2 and MMP13 expression, suggesting that Mmp12 was promoting fibrosis by limiting the expression of specific ECM degrading MMPs. Interestingly, like MMP12, MMP13 expression was highly dependent on IL-13 and type II-IL-4 receptor signaling ... However, in contrast to MMP12, expression of MMP13 was significantly suppressed by the endogenous IL-13 decoy receptor, IL-13Ralpha2
Saw et al., Am J Pathol 2011 (Fibrosis...) : Differences between pemphigoid and normal conjunctival fibroblasts with respect to collagen contraction and MMP secretion in the presence of interleukin-13 were also observed
Fujisawa et al., Int J Cancer 2012 (Neoplasm Invasiveness...) : Mechanistically, IL-13 enhanced ERK1/2, AP-1 and MMP activities only in IL-13Ra2 positive cells but not in IL-13Ra2 negative cells
Ito et al., Ultrasound Med Biol 2012 : Low-intensity pulsed ultrasound inhibits messenger RNA expression of matrix metalloproteinase-13 induced by interleukin-1ß in chondrocytes in an intensity dependent manner
Culley et al., Arthritis Rheum 2013 (Disease Models, Animal...) : Knockdown of each class I HDAC diminished interleukin-1 induced MMP13 expression