◀ Back to MAPK13
MAP2K3 — MAPK13
Pathways - manually collected, often from reviews:
-
BioCarta keratinocyte differentiation:
MEK3 (MAP2K3)
→
MAPK13
(modification, activates)
-
KEGG Toll-like receptor signaling pathway:
MAP2K3/MAP2K6
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, phosphorylation)
-
KEGG Fc epsilon RI signaling pathway:
MAP2K3/MAP2K6
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
KEGG GnRH signaling pathway:
MAP2K3/MAP2K6
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
KEGG Amyotrophic lateral sclerosis (ALS):
MAP2K3
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
KEGG MAPK signaling pathway:
MAP2K3
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, phosphorylation)
-
KEGG Toxoplasmosis:
MAP2K3/MAP2K6
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
KEGG Influenza A:
MAP2K3/MAP2K6
→
MAPK11/MAPK12/MAPK13/MAPK14
(protein-protein, activation)
-
NCI Pathway Database Signaling mediated by p38-gamma and p38-delta:
MKK3 (MAP2K3)
→
p38 delta (MAPK13)
(modification, activates)
Keesler et al., Protein Expr Purif 1998*
Evidence: assay
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
MAPK13
—
MAP2K3
(interaction, mapped from grid kegg_pathways intact mint)
-
STRING interaction:
MAP2K3
—
MAPK13
(interaction, mapped from grid)
Text-mined interactions from Literome
Martel-Pelletier et al., Arthritis Rheum 1999
(Osteoarthritis) :
Within minutes, IL-17 induced the phosphorylation of
mitogen activated protein kinase kinase-1/2 ( MEK-1/2 ), -3/6 ( MKK-3/6 ), p44/42, p38, and inhibitor of nuclear factor kappaB ( I kappaB)-alpha, as well as the
activation of
mitogen activated protein kinase activated protein kinase-1 and -2 ( MAPKAPK-1 and -2 )
Tu et al., J Biomed Sci 2001
(Carcinoma, Hepatocellular) :
On the other hand, PD98059, a specific inhibitor of
mitogen activated protein kinase kinase ,
blocks TPA induced
MAPK activation but has no effect on TPA induced tyrosine phosphorylation
Huang et al., Biochem Biophys Res Commun 2003
:
MAP3Ks are components of a three tiered protein kinase pathway in which a MAP3K phosphorylates and activates a
mitogen activated protein kinase kinase ( MAP2K ), which in turn
activates a
mitogen activated protein kinase ( MAPK )
Wu et al., Free Radic Biol Med 2010
(Drug-Induced Liver Injury) :
This was followed by
activation of
MKK3/MKK6 and MKK4/MKK7 at 4-8 or 12h and then JNK/p38
MAPK at 8 to 12h
Huwiler et al., Br J Pharmacol 1994
:
2. Both nucleotides stimulate phosphorylation and
activation of
mitogen activated protein kinase and a biphasic phosphorylation of the up-stream
mitogen activated protein kinase kinase
Daum et al., FEBS Lett 1998
:
Pervanadate inhibits
mitogen activated protein kinase kinase-1 in a
p38MAPK dependent manner