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SST — SSTR5

Pathways - manually collected, often from reviews:

• Reactome Reaction: SST → SSTR5 (direct_complex) Yamada et al., Mol Endocrinol 1992*, Yamada et al., Proc Natl Acad Sci U S A 1992*, Yamada et al., Biochem Biophys Res Commun 1993*
• Reactome Reaction: SST → SSTR5 (reaction) Yamada et al., Mol Endocrinol 1992*, Yamada et al., Proc Natl Acad Sci U S A 1992*, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Takami et al., Brain Res Mol Brain Res 1994, Yamada et al., Biochem Biophys Res Commun 1993*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SST — SSTR5 (in vivo) Panetta et al., Mol Pharmacol 1994*
• IRef Ophid Interaction: SST — SSTR5 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: SST — SSTR5 (aggregation, confirmational text mining) Panetta et al., Mol Pharmacol 1994*

Text-mined interactions from Literome

Li et al., Cancer 2011 (Carcinoma, Pancreatic Ductal...) : Somatostatin (SST) inhibited cell proliferation and negatively regulated the release of growth hormones by means of specific receptors ( SSTR )
Zhou et al., Mol Endocrinol 2012 (Insulinoma) : Taken together, our studies demonstrated that SSTR5 is a negative regulator for PDX-1 expression and that SSTR5 may mediate the inhibitory effects of somatostatin and its analogs on insulin expression/secretion and cell proliferation via down regulating PDX-1 at both transcriptional and posttranslational levels
Peng et al., Int J Mol Med 1998 : These findings show that SSTR is expressed in skeletal muscle and that SST acting via the SSTR regulates tyrosine phosphorylation and expression of the epsilon subunit of the AChR in the rat skeletal muscle