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CXADR — PTHLH

Text-mined interactions from Literome

MacLeod et al., Biochem Biophys Res Commun 2004 : AG1478, an EGFR kinase inhibitor, prevented the CaR mediated increases of pERK and PTHrP release, while AG1296, a PDGFR kinase inhibitor, had no effect
Ardeshirpour et al., Bone 2006 : These data provide genetic confirmation that the CaR regulates PTHrP production and calcium transport in the lactating mammary gland
Mihai et al., Eur J Surg Oncol 2006 (Bone Neoplasms...) : The CaR controls secretion of PTHrP in several breast cancer cell lines and PTHrP is known to stimulate osteolysis during metastatic bone resorption
Mamillapalli et al., J Biol Chem 2008 (Bone Neoplasms...) : In this study, we confirmed that the CaR inhibits PTHrP production by MMECs but stimulates PTHrP production by Comma-D cells ( immortalized murine mammary cells ) and MCF-7 human breast cancer cells ... We found that changes in intracellular cAMP, but not phospholipase C or MAPK signaling, correlated with the opposing effects of the CaR on PTHrP production ... Inhibition of protein kinase A activity mimicked the effects of CaR activation on inhibiting PTHrP secretion by MMECs and blocked the effects of the CaR on stimulating PTHrP production in Comma-D and MCF-7 cells ... Thus, the opposing effects of the CaR on PTHrP production are because of alternate G-protein coupling of the receptor in normal versus transformed breast cells