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IGF1 — STAR

Text-mined interactions from Literome

Mamluk et al., Biol Reprod 1999 : Both insulin and insulin-like growth factor I enhanced StAR gene expression in LGC
Pescador et al., Biol Reprod 1999 : It is concluded that StAR expression characterizes luteinization, and early luteinization is induced by cAMP and IGF-I in vitro
Le Roy et al., Endocrinology 2000 : IGF-I also enhanced StAR mRNA levels within 1.5 h, and these levels remained fairly constant
Sekar et al., Endocrinology 2000 : Together, these investigations document a significant role for insulin or IGF-I in enhancing LH-stimulated progesterone and cAMP biosynthesis and endogenous StAR message and protein accumulation and in augmenting cAMP-PKA dependent transcriptional activation of the exogenous StAR promoter
Eimerl et al., Biol Reprod 2002 : Each of these genes responded to FSH and/or IGF-1 in a characteristic manner : A synergistic action of IGF-1 was indispensable for FSH induction of P450 ( scc ) mRNA and protein ; IGF-1 did not affect FSH mediated upregulation of StAR products ; and IGF-1 alone was enough to promote expression of 3beta-HSD
LaVoie et al., Endocrinology 2004 : Concerted regulation of the porcine steroidogenic acute regulatory protein gene promoter activity by follicle stimulating hormone and insulin-like growth factor I in granulosa cells involves GATA-4 and CCAAT/enhancer binding protein beta
Manna et al., Mol Endocrinol 2006 : Molecular mechanisms of insulin-like growth factor-I mediated regulation of the steroidogenic acute regulatory protein in mouse leydig cells ... Interestingly, inhibition of ERK activity enhanced IGF-I mediated StAR protein expression, but phosphorylation of StAR was undetectable, an observation in contrast to that seen with N, O'-dibutyrl-cAMP signaling ... Transcriptional activation of the StAR gene by IGF-I was influenced by several transcription factors, its up-regulation being dependent on phosphorylation of the cAMP response element binding protein ( CREB ) and the activator protein 1 family member, c-Jun
Tosca et al., Domest Anim Endocrinol 2008 : AICAR treatment ( 1mM, 36h ) increased IGF-1 induced progesterone secretion, StAR protein levels and decreased ERK phosphorylation in F1 granulosa cells ... Adenovirus mediated expression of dominant negative AMPK totally reversed the effects of AICAR on IGF-1 induced progesterone secretion, StAR protein production and ERK phosphorylation in both F3/4 and F1 granulosa cells
Balasubramanian et al., Endocrinology 1997 : Regulation of porcine granulosa cell steroidogenic acute regulatory protein ( StAR ) by insulin-like growth factor I : synergism with follicle stimulating hormone or protein kinase A agonist ... We generated a partial porcine StAR complementary DNA ( 280 bp ) by RT-PCR and used the corresponding antisense riboprobe to quantify the control of StAR gene expression by FSH and insulin-like growth factor I (IGF-I) in hormonally responsive swine granulosa cells, which typically manifest synergistic steroidogenic stimulation by these two dominant intrafollicular regulators ... Treatment with FSH ( 1.6-fold ) or IGF-I ( 2.7-fold ) alone had a small but consistent stimulatory effect on StAR message accumulation ( corrected for 18S ribosomal RNA in each lane ) at 48 h, whereas only IGF-I stimulated StAR protein expression ( at least 6-fold as assessed by Western blot )
Lin et al., Endocrine 1998 : In the present study, we evaluate the effect of IGF-I on the gene expression and protein levels of steroidogenic acute regulatory protein ( StAR ), the rate limiting step in steroidogenesis ... Synergistic effects of IGF-I and hCG on StAR mRNA levels were confirmed by ribonuclease protection assay (RPA) ... To evaluate whether increased StAR mRNA levels induced by IGF-I and hCG are associated with increased StAR protein levels, we carried out Western blot analyses ... In the presence of IGF-I ( 100 ng/mL ), hCG induced StAR protein levels were further increased
LaVoie et al., Endocrinology 1999 : IGF-I significantly augmented PKA pathway agonist activation of the StAR promoter, whereas IGF-I had no effect alone