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BMP1 — BMP4
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
STRING interaction:
BMP1
—
BMP4
(interaction, mapped from grid bind dip)
-
STRING interaction:
BMP4
—
BMP1
(interaction, mapped from grid)
Text-mined interactions from Literome
Howard et al., Development 2000
:
The expression of the dHAND gene is controlled by bone morphogenetic proteins ( BMPs ), as suggested by
BMP4 overexpression in vivo and in vitro, and by noggin mediated
inhibition of
BMP function in vivo
Endo et al., Development 2002
:
In previous studies,
BMP4 has been shown to pattern the ectodermal tissues, and
BMP4 can
induce neural crest cells from the neural plate
Tsumaki et al., J Bone Miner Res 2002
:
Conversely, specific
BMP signals were
activated in the skeleton by targeted expression of
Bmp4 in cartilage and the resultant phenotype was compared with that of transgenic mice expressing growth and differentiation factor-5 ( GDF-5 ), another BMP family member
Pappano et al., Mol Cell Biol 2003
:
However, in vivo evidence of
roles for
BMP-1 and mTLL-1 in
BMP signaling in mammals is lacking
Takeda et al., Biochem Biophys Res Commun 2003
(Adenoma...) :
As for BMPs,
BMP-6 and -7 were
detected in NF-omas while
BMP-4 and -15 were not detected in either type of adenoma
Xu et al., Cell Biol Int 2004
:
BMP-4 and -5
increased the levels of osteopontin,
BMP-2 , alkaline phosphatase and core binding factor alpha 1 mRNAs
Sharov et al., Proc Natl Acad Sci U S A 2005
:
BMP-4 stimulates the expression of Agouti transcripts and protein in primary epidermal keratinocytes, and
BMP signaling positively
regulates dermal papilla-specific enhancer of the Agouti gene in primary dermal fibroblasts
Xia et al., J Biol Chem 2007
:
Furthermore, in BmpRII-null pulmonary artery smooth muscle cells, BMP2 and
BMP4 signaling was reduced by inhibition of endogenous RGMa expression, and RGMa mediated
BMP signaling
required ActRIIA expression
Foppiano et al., Dev Biol 2007
:
These data indicate that
BMP signaling mediates interactions between tissues in the FNP that regulate FEZ formation ; and that the correct pattern of Bmp2 and
Bmp4 , but not Bmp7, expression in the FNP mesenchyme
requires signaling by the BMP pathway
Zhao et al., Biochem Biophys Res Commun 2008
:
These data suggest that icariin exerts its potent osteogenic effect through induction of Runx2 expression, production of
BMP-4 and
activation of
BMP signaling
Lintern et al., J Biol Chem 2009
:
The Wise deletion construct lacking the LRP6 interacting loop domain nevertheless binds
BMP4 and
inhibits BMP signals
Clever et al., Am J Physiol Cell Physiol 2010
:
In addition, these cells secreted mature
BMP-4 , and
BMP signaling could be
inhibited with exogenous Noggin, causing a reduction in pSmad1/5/8, Id1, and Id3 levels
Canty-Laird et al., Biol Reprod 2010
:
BMP1 also
promotes BMP signaling by releasing BMP signaling molecules from complexes with the BMP-antagonist chordin
Tsukamoto et al., Mol Cell Endocrinol 2013
(MAP Kinase Signaling System) :
On the other hand,
BMP-4 induced Smad1/5/8 phosphorylation and the expression of a
BMP target gene, Id-1, were augmented in the presence of melatonin and ramelteon
Tovar-Vidales et al., Invest Ophthalmol Vis Sci 2013
:
The purpose of our study was to determine whether cultured human trabecular meshwork ( TM ) cells express BMP1, BMP1 expression is regulated by TGF-ß2,
BMP1 is biologically active, and
BMP1 regulates LOX activity
Israel et al., Growth Factors 1996
:
Transient co-expression of BMP-2 with either BMP-5, BMP-6 or BMP-7, or
BMP-4 transiently co-expressed with BMP-7,
resulted in more
BMP activity than expression of any single BMP