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EIF4EBP1 — PI3

Text-mined interactions from Literome

Rao et al., J Biol Chem 1999 : These findings demonstrate that 1 ) PI3-kinase dependent and independent mechanisms appear to be involved in PGF2alpha induced activation of ERK2 ; 2 ) PGF2alpha induced eIF4E and 4E-BP1 phosphorylation appear to be mediated by both ERK dependent and PI3-kinase dependent rapamycin-sensitive mechanisms ; and 3 ) ERK dependent eIF4E phosphorylation but not PI3-kinase dependent p70 ( S6k ) activation correlates with PGF2alpha induced global protein synthesis and bFGF-2 expression in VSMC
Liu et al., J Biol Chem 2002 : The PI3-kinase inhibitor, wortmannin, did not block UVB induced 4E-BP1 phosphorylation, but blocked both UVB- and insulin induced activation of PI3-kinase and phosphorylation of Akt
Kam et al., FASEB J 2004 : Mitogens activate protein translation through phosphorylation of p7S6 kinase ( p70 ( S6K ) ) and eIF4E binding protein 1 ( 4E-BP1 ) mediated by the mammalian target of rapamycin (mTOR) or phosphoinositide 3-kinase (PI3K)
Dutton et al., J Pathol 2005 (Hodgkin Disease) : Furthermore, LY294002 inhibited phosphorylation of p70 S6 kinase and 4E-BP1, suggesting that the phosphorylation of p70 S6 kinase and 4E-BP1 in HL cells is PI3-kinase dependent