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ARF6 — CYTH2

Pathways - manually collected, often from reviews:

• NCI Pathway Database Arf6 signaling events: ARF6/GDP complex (ARF6) → ARNO/beta Arrestin1-2 complex (CYTH2-ARRB2_ARRB1) (modification, collaborate)
  Claing et al., J Biol Chem 2001*
  Evidence: assay, physical interaction
• NCI Pathway Database Arf6 signaling events: ARNO/beta Arrestin1-2 complex (CYTH2-ARRB2_ARRB1) → ARF6/GTP complex (ARF6) (modification, collaborate) Claing et al., J Biol Chem 2001*
  Evidence: assay, physical interaction
• NCI Pathway Database Arf6 signaling events: ARNO (CYTH2) → ARF6/GTP complex (ARF6) (modification, activates) Macia et al., J Biol Chem 2001*, Santy et al., J Cell Biol 2001*, Yano et al., Mol Biol Cell 2008*, Frank et al., J Biol Chem 1998*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Arf6 signaling events: ARF6/GTP complex (ARF6) → ARNO (CYTH2) (translocation, activates) Cohen et al., Mol Biol Cell 2007*
  Evidence: assay, physical interaction
• NCI Pathway Database Arf6 signaling events: GNAQ/ARNO complex (GNAQ-CYTH2) → ARF6/GDP complex (ARF6) (modification, activates) Giguère et al., Cell Signal 2006*, Laroche et al., Mol Cell Biochem 2007*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Class I PI3K signaling events: ARNO (CYTH2) → ARF6/GDP complex (ARF6) (modification, activates) Frank et al., J Biol Chem 1998*
  Evidence: assay
• NCI Pathway Database Arf6 signaling events: IPCEF1/ARNO complex (IPCEF1-CYTH2) → ARF6/GDP complex (ARF6) (modification, activates) Venkateswarlu et al., J Biol Chem 2003
  Evidence: mutant phenotype, assay, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: CYTH2 — ARF6 Renault et al., Nature 2003*
• IRef Bind_translation Interaction: CYTH2 — ARF6 (x-ray crystallography) Renault et al., Nature 2003*
• IRef Biogrid Interaction: ARF6 — CYTH2 (direct interaction, enzymatic study) Frank et al., J Biol Chem 1998*
• IRef Biogrid Interaction: ARF6 — CYTH2 (physical association, affinity chromatography technology) Yano et al., Mol Biol Cell 2008*
• IRef Dip Interaction: Complex of ARF6-CYTH2-IRS1-INSR-CYTH3 (anti bait coimmunoprecipitation) Hafner et al., Nature 2006*
• IRef Hprd Interaction: CYTH2 — ARF6 (in vitro) Frank et al., J Biol Chem 1998*
• IRef Hprd Interaction: CYTH2 — ARF6 (in vivo) Frank et al., J Biol Chem 1998*
• IRef Ophid Interaction: ARF6 — CYTH2 (aggregation, confirmational text mining) Frank et al., J Biol Chem 1998*
• IRef Ophid Interaction: ARF6 — CYTH2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Vitale et al., J Cell Biol 2002 : Calcium regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane
Jayaram et al., Biochem Pharmacol 2011 : Arf nucleotide binding site opener [ ARNO ] promotes sequential activation of Arf6 , Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets ... Herein, we tested the hypothesis that Arf nucleotide binding site opener [ ARNO ], a guanine nucleotide-exchange factor [GEF ] for the small G-protein Arf6, mediates the functional activation of Arf6 , and that ARNO/Arf6 signaling axis, in turn, controls the activation of Cdc42 and Rac1, which have been implicated in GSIS