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F2RL1 — IL6
Text-mined interactions from Literome
Asokananthan et al., J Immunol 2002
:
PAR-1,
PAR-2 , or PAR-4, in combination,
caused additive
IL-6 release, but only the PAR-1 and PAR-2 combination resulted in an additive IL-8 response
Lang et al., Invest Ophthalmol Vis Sci 2003
:
HCE-T expression of cytokines (
IL-6 , IL-8, and TNFalpha ) in
response to activation of
PAR-1 and -2 was measured by quantitative RT-PCR and ELISA
Hirota et al., Hum Reprod 2005
(Endometriosis...) :
Activation of
PAR2 stimulated the proliferation of ESC and the secretion of
IL-6 and IL-8 from ESC in a dose dependent manner
Li et al., Immunol Cell Biol 2006
(Inflammation) :
Induction of
IL-6 release from human T cells by PAR-1 and
PAR-2 agonists
Rudack et al., Clin Exp Allergy 2007
(Acute Disease...) :
PAR-2 activation
regulates IL-8 and GRO-alpha synthesis by NF-kappaB, but not RANTES,
IL-6 , eotaxin or TARC expression in nasal epithelium
Amiable et al., Bone 2009
(Bone Resorption...) :
Activation of
PAR-2 with a specific agonist, SLIGKV-NH ( 2 ),
induced a significant up-regulation of MMP-1, MMP-9,
IL-6 , and membranous RANKL, but had no effect on MMP-13 or OPG production
Saito et al., Hum Reprod 2011
(Endometriosis...) :
Effects of TGF-ß type 1 inhibitor, SB431542, and PAR2 small interfering RNA ( siRNA ) on the TGF-ß1 stimulation of PAR2 gene expression and
PAR2AP induced
IL-6 secretion were also evaluated ... Activation of
PAR2 with PAR2AP
increased the secretion of
IL-6 from ESCs ... As expected, TGF-ß1 pretreatment dose-dependently enhanced the
PAR2AP induced increase in
IL-6 secretion from ESCs ... Treatment of ESCs with the TGF-ß type 1 inhibitor, SB431542, inhibited both TGF-ß1-stimulation of PAR2 gene expression and
PAR2AP induced
IL-6 secretion
Osuga et al., Front Biosci (Elite Ed) 2012
(Endometriosis) :
PAR2 activation in endometriotic stromal cells
increases secretion of
IL-6 and IL-8, and the number of the cells
Zhang et al., Cell Physiol Biochem 2012
(MAP Kinase Signaling System) :
Inhibition of
PAR-2 activation
reduced tryptase induced TNF-alpha,
IL-6 and ROS production, and mitochondrial membrane potential loss in microglia
Osuga et al., Front Biosci (Schol Ed) 2012
(Endometriosis) :
PAR2 activation in endometriotic stromal cells
increases secretion of
IL-6 and IL-8, and the number of the cells