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CCL2 — PI3

Text-mined interactions from Literome

Kodama et al., Am J Physiol Cell Physiol 2005 : Consistently, the increase in CHOP expression significantly reduced the MCP-1 promoter activity induced by PI3-kinase
Venkatesan et al., Cell Signal 2006 : We therefore examined the role of PI 3 kinase signaling in regulating the IFN-gamma induced MCP-1 expression in mesangial cells
Harvey et al., Arterioscler Thromb Vasc Biol 2007 (Atherosclerosis) : The IFN-gamma induced expression of MCP-1 in macrophages was attenuated by inhibitors of phosphoinositide-3-kinase (PI3K) , casein kinase 2 ( CK2 ), and Janus kinase (JAK)-2
Oyama et al., Lab Invest 2010 (Granuloma...) : HMGB1 also induced MCP-1 secretion through mitogen activated protein kinase ( MAPK ) and phosphoinositide-3-kinase (PI3K) pathways in rat renal tubular epithelial cells in vitro
Tom et al., Eur J Cell Biol 2013 (Inflammation) : Both inhibition of PI3kinase ( with wortmannin ) and NF?B ( with BAY11-7085 ) prevented ASP stimulation of MCP-1 and KC secretion in adipocytes
Turner et al., J Biol Chem 1998 : MCP-1 also stimulates an increase in the in vitro lipid kinase activity present in immunoprecipitates of the class 1A p85/p110 heterodimeric PI 3-kinase , although the kinetics of activation were much slower than observed for the accumulation of PI 3,4,5-P3 ... In addition, MCP-1 stimulated lipid kinase activity present in immunoprecipitates of a class II PI 3-kinase ( PI3K-C2alpha ) with kinetics that closely resembled the accumulation of PI 3,4,5-P3 ... This is the first demonstration that MCP-1 can stimulate PI 3-kinase activation and is also the first indication of an agonist induced activation of the PI3K-C2alpha enzyme