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EPHB2 — FLT1
Text-mined interactions from Literome
Kato et al., Biochem Biophys Res Commun 2001
:
Although SPARC derived peptide showed an angiogenic effect, intact SPARC itself inhibited the mitogenic activity of vascular endothelial growth factor ( VEGF ) for ECs by the inhibiting phosphorylation of
flt-1 ( VEGF receptor 1 ) and subsequent
ERK activation
Lichtenberger et al., Cell 2010
(Carcinoma, Squamous Cell...) :
Mechanistically, K5-SOS upregulates VEGF,
Flt1 , and Neuropilin-1 in an
Erk dependent manner, thereby activating an autocrine proliferation loop, whereas EGFR prevents tumor cells from apoptosis
Boscolo et al., Am J Pathol 2011
(Cell Transformation, Neoplastic...) :
We report here that VEGF-A or VEGF-B induces
VEGFR-1 mediated
ERK1/2 phosphorylation in HemSCs and promotes differentiation of HemSCs to endothelial cells ... Furthermore, the down-regulation of
VEGFR-1 in the HemSCs results in decreased formation of blood vessels in vivo and
reduced ERK1/2 activation
Ho et al., Circulation 2012
(Cardiomyopathies) :
VEGFR-1 knockout led to abundant accumulation of VEGFR-2 at the protein level, increased VEGFR-2 tyrosine phosphorylation transiently, and
enhanced serine phosphorylation of Akt and
ERK