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CDC42 — VAV1

Pathways - manually collected, often from reviews:

• KEGG T cell receptor signaling pathway: VAV1/VAV2/VAV3 → CDC42/RHOA (protein-protein, activation)
• KEGG Fc gamma R-mediated phagocytosis: VAV1/VAV2/VAV3 → CDC42 (protein-protein, activation)
• KEGG Leukocyte transendothelial migration: VAV1/VAV2/VAV3 → CDC42 (protein-protein, activation)
• KEGG Chemokine signaling pathway: VAV1/VAV2/VAV3 → CDC42 (protein-protein, activation)
• NCI Pathway Database TCR signaling in naïve CD4+ T cells: LAT/GRAP2/SLP76/VAV1/NCK1 complex (LAT-GRAP2-LCP2-VAV1-NCK1) → CDC42/GDP complex (CDC42) (modification, activates) Zeng et al., J Immunol 2003, Aspenström et al., Curr Biol 1996, Crespo et al., Nature 1997
  Evidence: assay
• NCI Pathway Database CXCR4-mediated signaling events: RAC1-CDC42/GDP complex (RAC1_CDC42) → SDF1/CXCR4/VAV1 complex (CXCL12-CXCR4-VAV1) (modification, collaborate)
  Vicente-Manzanares et al., Blood 2005, García-Bernal et al., Mol Biol Cell 2005
  Evidence: mutant phenotype, assay
• Reactome Reaction: VAV1 → CDC42 (reaction) Reid et al., J Biol Chem 1999, Schmidt et al., Genes Dev 2002, Jaffe et al., Annu Rev Cell Dev Biol 2005, Ramos-Morales et al., Oncogene 1995, Pasteris et al., Cell 1994, Hart et al., J Biol Chem 1994, Hart et al., J Biol Chem 1996, Zheng et al., J Biol Chem 1996, Han et al., Mol Cell Biol 1997*, Van Aelst et al., Genes Dev 1997, Ren et al., J Biol Chem 1998
• WikiPathways Chemokine signaling pathway: VAV1/VAV2/VAV3 → CDC42 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: VAV1 — CDC42 (physical association, affinity chromatography technology) Kaminuma et al., Mol Cell Biol 2001*
• IRef Hprd Interaction: VAV1 — CDC42 (in vivo) Kaminuma et al., Mol Cell Biol 2001*
• IRef Intact Interaction: VAV1 — CDC42 (direct interaction, fluorescence technology) Rapley et al., EMBO Rep 2008*
• IRef Ophid Interaction: VAV1 — CDC42 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Kaminuma et al., Mol Cell Biol 2001 : On the other hand, Vav induced the activation of Rac1 or Cdc42 and c-Jun N-terminal kinase (JNK), enhanced the transcriptional and DNA binding activities of AP-1, and induced increased phosphorylation of c-Jun
Ambrogio et al., Cancer Res 2008 (Lymphoma, Large-Cell, Anaplastic) : VAV1 increased Cdc42 activity, and in turn, Cdc42 regulated the shape and migration of ALCL cells
Olson et al., Curr Biol 1996 : FGD1 activates Cdc42, whereas Vav activates Rho, Rac and Cdc42