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DLG4 — PI3

Text-mined interactions from Literome

Lee et al., J Biol Chem 2005 : This insulin induced increase in the PSD-95 protein expression was inhibited by the tyrosine kinase inhibitor, AG1024, phosphatidylinositol 3-kinase (PI3K) inhibitors, LY294002 and wortmannin, translational inhibitors, anisomycin and rapamycin, but not by LY303511 ( an inactive analogue of LY294002 ), and transcriptional inhibitor, actinomycin D, suggesting that insulin regulates the translation of PSD-95 by activating the receptor tyrosine kinase-PI3K-mammalian target of rapamycin (mTOR) signaling pathway
Chamniansawat et al., Neurosci Lett 2010 : However, the block of PI-3K signaling by Wortmannin partially suppressed estrogen ( 48 h ) -induced PSD-95 and SYP expression, suggesting a crosstalk mechanism between genomic and non-genomic actions of estrogen on synaptic plasticity