Eckerle et al., Cancer Lett 2009
(Neuroblastoma) :
Deregulated MYCN indirectly induces BIRC5 through suppression of CDKN1A/p21 ( Cip1 ) and induction of Skp2, which in turn favors the degradation of p27 ( Kip1 )
Nakada et al., Jpn J Clin Oncol 1993
(Adrenal Gland Neoplasms...) :
There was a tendency for p21 expression to be low in N-myc ( + ) tumors, whereas p21 expression was frequently detected when N-myc expression was absent