Gene interactions and pathways from curated databases and text-mining

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ERBB2 — VEGFA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: VEGFA → ERBB2 (increases, VEGFA Activity)
    Evidence: Herceptin treatment of ErbB2 overexpressing tumor cells decreases expression of proangiogeneic factors including VEGF and TGF-alpha, resulting in a dramatic change in the tumor vasculature and a decrease in tumor size [123].
  • KEGG Focal adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PDGFC/PDGFD/PGF/VEGFA/VEGFB/VEGFC → EGFR/ERBB2/FLT1/FLT4/IGF1R/KDR/MET/PDGFRA/PDGFRB (protein-protein, activation)
  • WikiPathways Focal Adhesion: EGF/FIGF/HGF/IGF1/PDGFA/PDGFB/PGF/PDGFC/PDGFD/VEGFA/VEGFB/VEGFC → BLK/EGFR/ERBB2/FGR/FLT1/HCK/IGF1R/KDR/MET/PDGFRA/PDGFRB/PTK6/SRMS/TXK/TESK2/STYK1/TNK2/TNK1 (activation)

Text-mined interactions from Literome

Saucier et al., Proc Natl Acad Sci U S A 2004 (Neoplasms...) : The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
Finkenzeller et al., Angiogenesis 2004 (Cell Transformation, Neoplastic) : Activated Neu/ErbB-2 induces expression of the vascular endothelial growth factor gene by functional activation of the transcription factor Sp 1
Loureiro et al., Biochem Biophys Res Commun 2005 : ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter ... Mammary tumor cells overexpressing ErbB2 ( NAFA cells ) and a normal mouse mammary cell line ( HC11 ) transfected with ErbB2 expression vectors were used to study the effects of ErbB2 overexpression on VEGF regulation
Klos et al., Cancer Res 2006 (Breast Neoplasms...) : ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
Fan et al., Ann Biomed Eng 2011 (Mammary Neoplasms, Animal) : Integrin ß4 signaling promotes mammary tumor cell adhesion to brain microvascular endothelium by inducing ErbB2 mediated secretion of VEGF ... Rather, it enhances ErbB2 dependent expression of VEGF by tumor cells