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INS — MMP14

Text-mined interactions from Literome

Hiden et al., Diabetes 2008 (Abortion, Spontaneous...) : MT1-MMP expression in first-trimester placental tissue is upregulated in type 1 diabetes as a result of elevated insulin and tumor necrosis factor-alpha levels ... The upregulated MT1-MMP expression in type 1 diabetes may be the result of higher maternal insulin and TNF-alpha levels
Boden et al., Diabetes 2008 (Hyperinsulinism) : FFA augmented the insulin mediated increases in MMP-2 ( from approximately 6- to approximately 11-fold ), MMP-9 ( from approximately 3- to approximately 23-fold ), MT1-MMP ( from approximately 8- to approximately 20-fold ), MMP-2 gelatinolytic activity ( from 2- to 3-fold ), and JNK and p38 mitogen activated protein kinase ( MAPK ) activities but decreased insulin mediated activation of PI3K and ERK1/2
Hiden et al., J Clin Endocrinol Metab 2012 (Diabetes, Gestational...) : Fetal insulin and IGF-II contribute to gestational diabetes mellitus ( GDM ) -associated up-regulation of membrane-type matrix metalloproteinase 1 ( MT1-MMP ) in the human feto-placental endothelium ... Pathophysiological levels of insulin and IGF-II, but not IGF-I and glucose, stimulated MT1-MMP expression in fpEC by phosphatidylinositol 3-kinase signals relayed through the insulin, but not IGF-I, receptor