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MMP14 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: SRC → Complex of CAV1-MMP14 (decreases, CAV1/MMP14 Activity) Labrecque et al., J Biol Chem 2004*
  Evidence: Most interestingly, the association of MT1-MMP with phosphorylated caveolin-1 induced the recruitment of Src and a concomitant inhibition of the kinase activity of the enzyme, suggesting that this complex may be involved in the negative regulation of Src activity.
• NCI Pathway Database Signaling events mediated by focal adhesion kinase: MT1-MMP (MMP14) → FAK/Src-Yes-Fyn/Endophilin-A2 complex (PTK2-YES1_SRC_FYN-SH3GL1) (endocytosis, collaborate)
  Wu et al., Dev Cell 2005
  Evidence: mutant phenotype

Text-mined interactions from Literome

Razandi et al., J Biol Chem 2003 (Breast Neoplasms) : This resulted from Src induced MMP activation , implicated using PP2 ( Src family kinase inhibitor ) or the expression of a dominant negative Src protein
Nyalendo et al., J Biol Chem 2007 (Neoplasms...) : Src dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573 : role in endothelial and tumor cell migration ... In this study, we show that MT1-MMP is phosphorylated on the unique tyrosine residue located within this cytoplasmic sequence ( Tyr ( 573 ) ) and that this phosphorylation requires the kinase Src ... Altogether, these findings strongly suggest that the Src dependent tyrosine phosphorylation of MT1-MMP plays a key role in cell migration and further emphasize the importance of the cytoplasmic domain of the enzyme in this process
Martinez-Orozco et al., Eur J Cell Biol 2010 (Neoplasm Invasiveness) : We demonstrate here that AA promotes an increase in vimentin and N-cadherin expression, MMP-9 secretion, a decrease in E-cadherin junctional levels, and the activation of FAK, Src and NF-kappaB in MCF10A cells
Shi et al., Mol Cell Biochem 2012 : The non-receptor tyrosine kinase c-Src mediates the PDGF induced association between Furin and pro-MT1-MMP in HPAC pancreatic cells ... Human platelet derived growth factor BB ( PDGF-BB ) activated c-Src and induced c-Src dependent association of Furin with pro-MT1-MMP in HPAC pancreatic cancer cells ... Association between Furin and MT1-MMP is regulated by the tyrosine kinase c-Src