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APOB — PPARA

Text-mined interactions from Literome

Delerive et al., FEBS Lett 2000 : Here, we show using transient transfection assays that oxidized ( oxLDL ) but not native low-density lipoproteins (LDL) dose-dependently activate PPARalpha in endothelial cells without affecting PPARalpha protein expression
Ziouzenkova et al., J Biol Chem 2003 (Inflammation) : We show here that MUT LDL activates PPAR alpha to an extent proportional to its LDL ( - ) content ... As compared with LDL ( - ) alone, LPL treated LDL ( - ) increased PPAR alpha activation 20-fold in either cell based transfection or radioligand displacement assays
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : However, the detailed mechanisms of Ox-LDL induced PPARalpha and PPARgamma activation are not fully understood ... In the present study, we investigated the effect of Ox-LDL on PPARalpha and PPARgamma activation in macrophages ... Ox-LDL , but not LDL, induced PPARalpha and PPARgamma activation in a dose dependent manner ... Ox-LDL transiently induced cyclooxygenase-2 (COX-2) mRNA and protein expression, and COX-2 specific inhibition by NS-398 or meloxicam or small interference RNA of COX-2 suppressed Ox-LDL induced PPARalpha and PPARgamma activation ... Ox-LDL induced phosphorylation of ERK1/2 and p38 MAPK, and ERK1/2 specific inhibition abrogated Ox-LDL induced COX-2 expression and PPARalpha and PPARgamma activation, whereas p38 MAPK-specific inhibition had no effect
Babaahmadi Rezaei et al., Iran Biomed J 2013 : Conclusion : It was confirmed that both EPA and ox-LDL increased CD36 expression but not PPAR-? , and also co-treatment with PPAR-? inhibitor decreased CD36 expression