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GNLY — IL15
Text-mined interactions from Literome
Ma et al., J Immunol 2002
:
CD8 T cell mediated killing of Cryptococcus neoformans requires
granulysin and is
dependent on CD4 T cells and
IL-15 ... Furthermore,
IL-15 was both necessary and
sufficient for
granulysin up-regulation in CD8 T cells
Hogg et al., J Leukoc Biol 2009
:
Induction of
granulysin in CD8+ T cells by IL-21 and
IL-15 is suppressed by human immunodeficiency virus-1 ... Using primary human CD8+ T cells, in this study, we identify IL-21 as a strong inducer of granulysin, demonstrate that IL-21 and
IL-15 activate
granulysin expression within CD8+ CD45RO+ T cells, and establish a role for Jak/STAT signaling in the regulation of granulysin within CD8+ T cells
Hogg et al., Tuberculosis (Edinb) 2011
(HIV Infections) :
Activation of NK cell
granulysin by mycobacteria and
IL-15 is differentially affected by HIV ... Infection of PBMC with HIV-1 suppresses NK cell
induction of
granulysin by
IL-15 , but does not impair activation by BCG