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GNA13 — PTGS2

Text-mined interactions from Literome

Slice et al., J Biol Chem 1999 : Using a transient transfection assay with a reporter vector in which the murine COX-2 promoter drives the production of luciferase and expression vectors encoding for alpha subunits of G-proteins, we show that overexpression of wild type and constitutively active Galpha(13) and Galpha ( q ) induced transcription from the COX-2 promoter ... Co-expression of Clostridium botulinum C3 toxin specifically blocked induction of the COX-2 promoter by either Galpha(13)Q226L or RhoQ63L but did not prevent the activation of this promoter by Ras, Rac, v-src, or forskolin
Ki et al., J Biol Chem 2007 : Gene knock-out and chemical inhibitor experiments revealed that the S1P induction of COX-2 requires Galpha(12) but not Galpha(13) , Galpha ( q ), or Galpha ( i/o )