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Wilson et al., Growth Horm IGF Res 2001 (Diabetic Retinopathy) : We examined the effect of IGF-I on human retinal endothelial cell ( HREC ) survival following high glucose exposure and serum starvation, examined the signalling pathways mediating the protective effect of IGF-I on HREC, and characterized somatostatin receptor induced retinal endothelial cell death
Giacconi et al., Mech Ageing Dev 2003 : Somatostatin is in turn affected by somatomedin-C , which is also zinc dependent
Eshet et al., J Mol Neurosci 2004 (Body Weight) : The effect of exogenous growth hormone (GH) and insulin-like growth factor I (IGF-I) on brain IGF-I binding sites ( IGF-IR ), and on the levels of growth hormone releasing hormone (GHRH) and somatostatin was studied in hypophysectomized and intact juvenile male rats ... However, in the hypophysectomized animals, GH and IGF-I treatment induced a significant increase in somatostatin levels ( 1300 +/- 193.7 pg/mg tissue, p < 0.01, and 912.5 +/- 81.2 pg/mg tissue, p < 0.05, respectively )
Sall et al., Exp Eye Res 2004 : Somatostatin and octreotide, a somatostatin analogue, inhibited IGF-1 receptor (IGF-1R) phosphorylation and decreased VEGF production
Selvarajah et al., Eur J Endocrinol 2005 (Acromegaly) : Somatostatin analogues (SAs) allow adequate control of GH and IGF-I in approximately 65 % of subjects, leaving a significant cohort uncontrolled
Vera Cruz et al., Horm Behav 2007 : Lower social status depressed hepatic IGF-I levels while dominant status stimulated hepatic IGF-I production, possibly in response to inhibition of somatostatin release in the hypothalamus, leading to greater secretion of pituitary growth hormone ( GH )
Very et al., FEBS Lett 2007 : Rainbow trout gill tissue was used to examine the role of somatostatin (SS) on insulin-like growth factor-I (IGF-I) receptor expression
Very et al., Mol Cell Endocrinol 2008 : Somatostatin inhibits basal and growth hormone stimulated hepatic insulin-like growth factor-I production
Flyvbjerg et al., Am J Physiol 1991 : We investigated the effect of a somatostatin analogue octreotide (SMS) on the stimulatory effect of recombinant human growth hormone ( hGH ) on insulin-like growth factor I (IGF-I) generation and growth in hypophysectomized rats
Rosskamp et al., Eur J Pediatr 1987 (Obesity) : Circulating somatomedin-C levels and the effect of growth hormone releasing factor on plasma levels of growth hormone and somatostatin-like immunoreactivity in obese children
Sheppard et al., Can J Physiol Pharmacol 1987 : Cycloheximide blocks insulin-like growth factor I but not somatostatin inhibition of growth hormone secretion
Blanchard et al., Reprod Nutr Dev 1987 : these data indicate that in prepubertal male lambs : the stimulatory effect of GRF is predominant over the inhibitory effect of SRIF, somatostatin inhibits TRH stimulation of GH secretion in vitro, and IGF-I may control GH secretion by modulating GRF effects at the pituitary level
Orskov et al., J Clin Endocrinol Metab 1994 (Hyperinsulinism) : Somatostatin stimulated insulin-like growth factor binding protein-1 release is abolished by hyperinsulinemia
Sato et al., Endocrinology 1993 (Dwarfism) : The roles of GH and insulin-like growth factor-I (IGF-I) in the regulation of hypothalamic GH-releasing hormone (GRH) and somatostatin ( SRIH ) gene expression were investigated in the GH-deficient dwarf ( dw ) rat, in which endogenous feedback signals are lacking
García de Lorenzo et al., Nutr Hosp 1995 : In this article we bring an up date of the role of insulin, anabolic steroids, blocking the catabolic hormones, phenobarbital, somatostatin , clenbuterol and metaprorenol, growth factors : GH and IGF-1 , cytokines, and anti-cytokines sera