◀ Back to CDH1
BMP7 — CDH1
Text-mined interactions from Literome
Veerasamy et al., American journal of physiology. Renal physiology 2009
(Fibrosis) :
Differential
regulation of
E-cadherin and alpha-smooth muscle actin by
BMP 7 in human renal proximal tubule epithelial cells and its implication in renal fibrosis ... We investigated the
effect of
BMP 7 on TGFbeta1 mediated
E-cadherin loss in two different transformed human adult proximal tubule epithelia
Gai et al., J Am Soc Nephrol 2009
:
In cultured metanephric mesenchymal cells,
Bmp7 induced Trps1 and
E-cadherin and downregulated vimentin
Zhou et al., Zhongguo Zhong Yao Za Zhi 2010
:
BMP-7 significantly
inhibited the down-regulation of
E-cadherin and the up-regulation of alpha-SMA induced by TGF-beta1 ( P < 0.05 ), and SA-B significantly inhibited the up-regulation of alpha-SMA expression induced by TGF-beta1 ( P < 0.05 ), but not the down-regulation of E-cadherin induced by TGF-beta1
Park et al., Development 2010
:
As
BMP signaling also induces cadherin 6B expression and
represses N-cadherin , cadherin regulated BMP signaling may create two opposing feedback loops
Wang et al., J Orthop Res 2012
:
We found that
E-cadherin induces the expression of BMP-4 and
BMP-7 genes and enhances Smad1/5 phosphorylation
Xu et al., Dig Dis Sci 2013
(Carcinoma, Squamous Cell...) :
In addition, inhibition of
BMP7 by siRNA also
leads to up-regulation of
E-cadherin and down-regulation of MMP-9 in the highly metastatic cell lines
Helbing et al., J Pathol 2013
(Lung Injury) :
Supporting this notion, pharmacological inhibition of
BMP signalling by LDN193189
prevented reduction of
E-cadherin and disruption of epithelial barrier function