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PLD2 — SYK
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Hitomi et al., FEBS Lett 1999
:
Cross linking of the B cell receptor
induces activation of
phospholipase D through
Syk , Btk and phospholipase C-gamma2 ... These results demonstrate that
Syk , Btk and PLC-gamma2 are
essential for BCR induced
PLD activation
Hitomi et al., Blood 2004
:
However, FcepsilonRI induced
PLD activation
required Syk and was downstream of the Ca ( 2+ ) response, suggesting that basal PLD1 activity rather than that activated by cell stimulation controlled these early signaling events
Lee et al., Blood 2006
:
Phospholipase D2 acts as an essential adaptor protein in the activation of
Syk in antigen stimulated mast cells ... Here we show that
PLD2 associates with and
promotes activation of
Syk , a key enzyme in mast cell activation