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GRP — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → GRP (increases, GRP Activity) Thomas et al., Neoplasia (New York, N.Y.) 2005*
  Evidence: GRP induced rapid activation of p44/42 MAPK in lung cancer cells through EGFR.
• OpenBEL Selventa BEL large corpus: MAPK1 → GRP (increases, GRP Activity, MAPK1 Activity) Xiao et al., Cell Signal 2003*
  Evidence: bombesin specifically induced mitogen-activated protein (MAP) kinase activation as shown by increased extracellular regulated kinase (ERK) phosphorylation and epidermal growth factor (EGF) receptor transactivation in prostate cancer cells, which express functional gastrin-releasing peptide receptor

Text-mined interactions from Literome

Lui et al., Oncogene 2003 (Carcinoma, Squamous Cell...) : In HNSCC cells that express elevated levels of both GRPR and EGFR, we found that GRP induced rapid phosphorylation of EGFR as well as p44/42-MAPK activation ... Using several EGFR-specific tyrosine kinase inhibitors and cells derived from EGFR knockout mice, we demonstrated that GRP induced p44/42-MAPK activation was dependent upon EGFR activation ... Further investigation demonstrated that cleavage of transforming growth factor-alpha ( TGF-alpha ) by matrix metalloproteinases mediated GRP induced MAPK activation
Zhang et al., Cancer Res 2004 (Carcinoma, Squamous Cell...) : Blockade of Src family kinases using an Src-specific tyrosine kinase inhibitor A-419259 decreased GRP induced EGFR phosphorylation and MAPK activation
Thomas et al., Neoplasia (New York, N.Y.) 2005 (Carcinoma, Non-Small-Cell Lung...) : GRP induced rapid activation of p44/42 MAPK in lung cancer cells through EGFR ... GRP mediated activation of MAPK in NSCLC cells was abrogated by pretreatment with the anti-EGFR neutralizing antibody, C225 ... Pretreatment of NSCLC cells with neutralizing antibodies to the EGFR ligands, TGF-A or HB-EGF, also decreased GRP mediated MAPK activation
Li et al., Oncol Rep 2010 (Carcinoma, Hepatocellular...) : GRP activated MAPK/ERK1/2 in HepG2 cells, leading to enhanced proliferation, reduced apoptosis and accelerated cell cycle progression ... GRP promotes the growth of HepG2 cells through interaction with GRPR co-expressed in tumor cells, and subsequently activates MAPK/ERK1/2 via EGFR independent mechanisms
Sharif et al., Mol Cell Endocrinol 1997 (Glioblastoma) : Stimulation of the glioblastoma cell line U-373MG with bombesin or gastrin releasing peptide (GRP) induced mitogenesis, measured by [ 3H ] thymidine incorporation into DNA, and stimulated the tyrosine phosphorylation of the mitogen activated protein ( MAP ) kinases ( Erk1 and Erk2 )