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CXCL12 — LPA

Text-mined interactions from Literome

Jeon et al., Stem Cells 2008 (Ascites...) : In addition, LPA increased the expression of SDF-1 in hADSCs, and pretreatment of the cells with Ki16425 or SB431562 attenuated the LPA stimulated expression of SDF-1 ... These results suggest that cancer derived LPA stimulates differentiation of hADSCs to myofibroblast-like cells and increases SDF-1 expression through activating autocrine TGF-beta1-Smad signaling pathway
Jeon et al., Exp Mol Med 2010 (Ovarian Neoplasms) : LPA activated RhoA in hASCs and pretreatment with the Rho kinase inhibitor Y27632 completely abrogated the LPA induced expression of alpha-SMA, SDF-1 , and VEGF in hASCs ... LPA induced VEGF secretion was inhibited by LY294002, whereas LPA induced SDF-1 secretion was markedly attenuated by U0126, U73122, and LY294002
Subramanian et al., Circ Res 2010 : Lysophosphatidic acid (LPA) induces CXCL12 and neointimal accumulation of smooth muscle cells ( SMCs ) in uninjured arteries ... In wild type mice, LPA20 : 4 increased CXCL12 and hypoxia-inducible factor-1alpha expression in carotid arteries as early as 1 day following short-term endoluminal incubation