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PDK1 — SLC2A4

Text-mined interactions from Literome

Bandyopadhyay et al., Mol Endocrinol 1999 : Overexpression of wild-type PDK-1 provoked increases in the activity of cotransfected hemagglutinin ( HA ) -tagged PKC-zeta and concomitantly enhanced HA-tagged GLUT4 translocation ... Expression of both kinase-inactive PDK-1 and an activation-resistant form of PKC-zeta that is mutated at Thr-410, the immediate target of PDK-1 in the activation loop of PKC-zeta, inhibited insulin induced increases in both HA-PKC-zeta activity and HA-GLUT4 translocation to the same extent as kinase-inactive PKC-zeta ... In contrast to the T410A PKC-zeta mutant, an analogous double mutant of PKB ( T308A/S473A ) that is resistant to PDK-1 activation had only a small effect on insulin stimulated HA-GLUT4 translocation and did not inhibit HA-GLUT4 translocation induced by overexpression of wild-type PDK-1
Grillo et al., FEBS Lett 1999 : We demonstrated that the overexpression of PDK1 ( 3-phosphoinositide dependent protein kinase 1 ), a downstream effector of PI 3-kinase, stimulated Glut 4 translocation in adipocytes