Gene interactions and pathways from curated databases and text-mining

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HIF1A — MITF

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: HIF1A → MITF (increases, MITF Activity, HIF1A Activity) Buscà et al., J Cell Biol 2005*
    Evidence: melanocyte-specific transcription factor, microphthalmia-associated transcription factor (MITF), binds to the Hif1a promoter and strongly stimulates its transcriptional activity. Further, MITF "silencing" abrogates the cAMP effect on Hif1a expression, and overexpression of MITF in human melanoma cells is sufficient to stimulate HIF1A mRNA
  • FastForward regulation: MITF → HIF1A (transcriptional regulation, increase) Buscà et al., J Cell Biol 2005*
    Evidence: REG, PROMACTIVITY, DNABINDING