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HMGA1 — TP53

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HMGA1 — TP53 (physical association, affinity chromatography technology) Aiello et al., Eur J Cancer 2010*

Text-mined interactions from Literome

Frasca et al., Cancer Res 2006 (Thyroid Neoplasms) : We now show that in thyroid cancer cells, HMGA1 down-regulation by small interfering RNA and antisense techniques results in enhanced transcriptional activity of p53 , TAp63alpha, TAp73alpha, and, consequently, increased apoptosis ... We now show that in thyroid cancer cells, HMGA1 down-regulation by small interfering RNA and antisense techniques results in enhanced transcriptional activity of p53 , TAp63alpha, TAp73alpha, and, consequently, increased apoptosis ... Moreover, inhibition of HMGA1 expression in thyroid cancer cells resulted in increased p53 oligomerization in response to the DNA damaging agent doxorubicin
Pierantoni et al., J Clin Invest 2007 (Breast Neoplasms...) : We found that HMGA1 overexpression promoted HIPK2 relocalization in the cytoplasm and inhibition of p53 apoptotic function, while HIPK2 overexpression reestablished HIPK2 nuclear localization and sensitivity to apoptosis