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Kanzaki et al., J Biol Chem 2000 : Furthermore, G ( q ) /Q209L did not induce the in vivo accumulation of phosphatidylinositol-3,4,5-trisphosphate ( PIP ( 3 ) ), whereas expression of the RGS proteins did not prevent the insulin stimulated accumulation of PIP ( 3 )
Blero et al., Biochem Biophys Res Commun 2001 : Overexpression of SHIP2 led to a decrease of the insulin dependent PIP3 production as well as Akt/PKB activation and MAPK stimulation
Keeton et al., Endocrinology 2005 (Carcinoma, Hepatocellular...) : In the present work, insulin 's regulation of expression of activating transcription factor 3 ( ATF-3 ), the putative transcription factor proline-rich induced protein (Pip)92 , and insulin-inducible gene-1 (Insig-1) ( an ER resident protein involved in regulation of sterol-responsive element binding protein 1 activation ) have been examined in a liver derived cell line ( rat H4IIE hepatoma cells ) ... We report that : 1 ) insulin induced transcription of ATF-3, Pip92, and Insig-1 required MEK-ERK activation ; 2 ) insulin induced transcription of ATF-3 and Pip92 reached maximum levels within 15 min and was blocked by wortmannin but not LY294002 ; 3 ) in contrast, the maximum level of insulin induced transcription of Insig-1 was delayed and was not blocked by either wortmannin or LY294002 ; 4 ) insulin activated ERK1/2 in two distinct phases, a rapid peak and a later plateau ; 5 ) the delayed plateau phase of insulin induced ERK1/2 activation was partially phosphatidylinositol 3-OH-kinase dependent ; and 6 ) however, the rapid, insulin induced peak of ERK1/2 activation was blocked by wortmannin but not LY294002
Strawbridge et al., Diabetes 2005 (Insulin Resistance) : Since endothelin (ET)-1 impairs insulin sensitivity and PIP ( 2 ) is a target of ET-1 induced signaling, we tested whether a change in insulin stimulated PIP ( 3 ) generation and signaling, PIP ( 2 ) -regulated actin polymerization, or a combination of both accounted for ET-1 induced insulin resistance ... Despite decreased insulin stimulated PI 3-kinase activity and PIP ( 3 ) generation, ET-1 did not diminish downstream signaling to Akt-2
Lauritzen et al., Diabetes 2008 : In high fat fed mice, a approximately 65 % reduction in both insulin induced T-tubular PIP3 production and GLUT4-GFP translocation was seen
Ernst et al., J Neurosci 2009 (Body Weight...) : This unexpected finding coincides with POMC-cell-specific, Stat3 mediated upregulation of SOCS3 expression inhibiting both leptin and insulin signaling as insulin stimulated PIP ( 3 ) ( phosphatidylinositol-3,4,5 triphosphate ) formation and protein kinase B ( AKT ) activation in POMC neurons as well as with the fact that insulin 's ability to hyperpolarize POMC neurons is largely reduced in POMC cells of Stat3-C ( POMC ) mice
Lopez et al., Am J Physiol Endocrinol Metab 2010 (Diabetes Mellitus, Type 2) : Diabetic mouse islets contain less active ERM, suggestive of a novel mechanism whereby impairment of insulin granule trafficking to the membrane through a complex containing F-actin, PIP2 , Exo70, and ERM proteins contributes to defective insulin secretion
Kalwa et al., J Biol Chem 2011 : The insulin stimulated increase in caveolar PIP ( 2 ) was blocked by siRNA mediated knockdown of MARCKS, as determined using both biochemical assays and imaging studies using FRET based PIP ( 2 ) biosensors
Manna et al., Mol Cell Biochem 2013 : Using a 3T3L1 adipocyte cell model, this study investigated the role of PIP3 and PIP2 on insulin stimulated glucose metabolism in high glucose ( HG ) treated cells
Wasner et al., Acta Diabetol 1997 (Diabetes Mellitus, Experimental...) : Upon measuring cyclic PIP levels after hormonal stimulation in all organs of diabetic rats, it was found that stimulation of cyclic PIP synthesis by insulin decreased gradually in a time dependent manner
Bortoff et al., Endocrine 1997 (Liver Neoplasms, Experimental) : Insulin induction of pip 92, CL-6, and novel mRNAs in rat hepatoma cells
Jiang et al., J Biol Chem 1998 : Insulin stimulation of hexose uptake into adipocytes was inhibited by the kinase inhibitor wortmannin and was largely restored by di-C8-PIP3/AM , which had no effect in the absence of insulin