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INS — PRKCZ

Text-mined interactions from Literome

Kanoh et al., J Biol Chem 2000 (Diabetes Mellitus, Experimental) : We evaluated effects of the thiazolidinedione, rosiglitazone, on insulin induced activation of protein kinase C (PKC)-zeta/lambda and glucose transport in adipocytes of Goto-Kakizaki ( GK ) -diabetic and nondiabetic rats
Valverde et al., FEBS Lett 2000 : Furthermore, insulin induced glucose uptake was totally abolished by the inhibitor in parallel with a total inhibition of insulin induced protein kinase C (PKC) zeta activity
Standaert et al., Biochemistry 2001 : Activation of protein kinase C-zeta (PKC-zeta) by insulin requires phosphatidylinositol (PI) 3-kinase dependent increases in phosphatidylinositol-3,4,5- ( PO ( 4 ) ) ( 3 ) ( PIP ( 3 ) ) and phosphorylation of activation loop and autophosphorylation sites, but actual mechanisms are uncertain
Oriente et al., J Biol Chem 2001 : Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells
Vollenweider et al., Diabetes 2002 (Glucose Intolerance...) : This insulin resistance was associated with impaired insulin receptor substrate (IRS)-2 associated phosphatidylinositol 3' (PI3) kinase activation and IRS-2 tyrosine phosphorylation as well as significantly decreased protein kinase C (PKC)-zeta/lambda activation in response to insulin
Cariou et al., Mol Cell Biol 2002 : The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta
Standaert et al., Diabetes 2002 (Diabetes Mellitus, Type 2...) : Skeletal muscle insulin resistance in obesity associated type 2 diabetes in monkeys is linked to a defect in insulin activation of protein kinase C-zeta/lambda/iota
Miura et al., Metabolism 2003 : Inhibitory effect of ceramide on insulin induced protein kinase Czeta translocation in rat adipocytes
Mur et al., Endocrinology 2003 : Activation of protein kinase Czeta by insulin was similar in both cell types as was insulin induced glucose uptake
Kanoh et al., Endocrinology 2003 (Diabetes Mellitus, Experimental) : Defective activation of atypical protein kinase C zeta and lambda by insulin and phosphatidylinositol-3,4,5- ( PO4 ) ( 3 ) in skeletal muscle of rats following high-fat feeding and streptozotocin induced diabetes
Steiler et al., Endocrinology 2003 (Diabetes Mellitus, Experimental...) : Under euglycemic and hyperglycemic conditions, basal and insulin stimulated action on phosphatidylinositol (PI) 3-kinase, protein kinase B/Akt, and ERK were reduced in GK rats, whereas insulin stimulated protein kinase C (PKC)zeta activity was not altered
Vigliotta et al., Mol Cell Biol 2004 (Diabetes Mellitus) : In vivo, insulin stimulated glucose uptake was decreased by almost 50 % in fat and muscle tissues of the ped/pea-15 transgenic mice, accompanied by protein kinase Calpha activation and block of insulin induction of protein kinase Czeta
Sajan et al., J Clin Endocrinol Metab 2004 (Obesity) : Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5- ( PO4 ) 3 in cultured preadipocyte derived adipocytes and myotubes of obese subjects
Akiba et al., Biochem Pharmacol 2004 : Although caffeine did not alter insulin induced activation of PI3K and protein kinase C-zeta (PKCzeta) , an isoform of atypical PKC, which is reported to have an important role in insulin induced GLUT4 translocation, we found that insulin induced phosphorylation and activation of Akt were blocked by pre-treatment with caffeine
Corbould et al., J Endocrinol 2007 (Insulin Resistance...) : In the glucose metabolic pathway of insulin signaling, treatment of cells with T 10 nmol/l did not alter insulin stimulated phosphorylation of insulin receptor substrate-1 or Akt, but insulin stimulated phosphorylation of protein kinase C (PKC) zeta was impaired
Saito et al., Metabolism 2008 : Of note was that insulin stimulated atypical protein kinase Czeta kinase activity toward TC10 was reduced by high-fat feeding but normalized by exercise training
Liu et al., Cell Signal 2010 : The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP activated protein kinase (AMPK) mediated glucose uptake in muscle cells
Mosthaf et al., Exp Clin Endocrinol Diabetes 1996 : Insulin leads to a parallel translocation of PI-3-kinase and protein kinase C zeta
Sweeney et al., Diabetologia 1998 : Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves phosphatidylinositol 3-kinase and protein kinase C-zeta