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INS — SSTR2

Text-mined interactions from Literome

Cheng et al., Life Sci 2002 : SSTR2 mediates the somatostatin induced increase in intracellular Ca ( 2+ ) concentration and insulin secretion in the presence of arginine vasopressin in clonal beta-cell HIT-T15
Brunicardi et al., Pancreas 2003 (Cadaver) : We demonstrated that the SSTR 2 agonist and octreotide significantly suppressed insulin secretion ... These results demonstrate that activation of SSTR 2 suppresses insulin secretion in the isolated perfused human pancreas
Slagter et al., Regul Pept 2005 : INS also regulated SSTR expression in a subtype- and tissue-specific manner ... INS reduced SSTR 1B expression in optic tectum, increased SSTR 2 expression in pancreas, and increased SSTR 1B and 2 expression in liver
Nelson et al., Am J Physiol Regul Integr Comp Physiol 2006 : INS stimulated SSTR2 expression to a greater extent than SSTR1A or SSTR1B expression, whereas GH stimulated SSTR2 and SSTR1B expression to a similar extent, with SSTR2 and SSTR1B expression being more responsive to GH than SSTR1A ... These findings indicate that INS and GH stimulate SSTR expression by regulating transcription of SSTR mRNAs and by increasing functional SSTRs on the cell surface, and they suggest that regulation of SSTRs may be important for the coordination of growth, development, and metabolism of vertebrates
Singh et al., J Clin Endocrinol Metab 2007 : SSTR1-, SSTR2- , and SSTR5-selective agonists inhibited insulin secretion with the following order of potency : SSTR2 ( EC50, 0.08 nm ) > SSTR5 ( EC50, 5.3 nm ) > SSTR1 ( EC50, 35 nm ) ... SSTR1-, SSTR2- , and SSTR5-selective agonists inhibited insulin secretion with the following order of potency : SSTR2 ( EC50, 0.08 nm ) > SSTR5 ( EC50, 5.3 nm ) > SSTR1 ( EC50, 35 nm )
Fagan et al., Surgery 1998 : This study was undertaken to determine which SSTR ( 2 or 5 ) is responsible for the inhibitory effect of somatostatin on glucose stimulated mouse insulin secretion