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BDNF — CEP250
Text-mined interactions from Literome
Evans et al., Med Pediatr Oncol 2001
(Neuroblastoma) :
The
effect of
CEP-751 on TrkB activation by
BDNF was examined in G12 cells in culture by immunoprecipitation with antipan Trk antiserum, followed by Western blot analysis using antiphosphotyrosine antibodies ... Activation of TrkB by
BDNF in G12 cells was
inhibited by
CEP-751 in a dose dependent fashion
Apostol et al., Mol Cell Neurosci 2008
(Disease Models, Animal...) :
CEP-1347 reduces mutant huntingtin associated neurotoxicity and
restores BDNF levels in R6/2 mice ... Finally,
CEP-1347 improved motor performance in R6/2 mice and
restored expression of
BDNF , a critical neurotrophic factor that is reduced in HD