Ido et al., Diabetes 2002
(Hyperglycemia) :
Likewise, expression of a constitutively active AMPK in HUVEC prevented the increase in caspase-3 activity
Meisse et al., FEBS Lett 2002
:
Prolonged AMPK activation triggered apoptosis and activated c-Jun N-terminal kinase (JNK) and caspase-3 Wu et al., Food Chem Toxicol 2013
:
Caspase-3 inhibitor also efficiently blocked CD95 ( APO-1/CD95 ) and Bax expression, caspase-3 activation and PARP cleavage, whereas antioxidant N-acetyl-l-cysteine, AMPK inhibitor and AMPK siRNA effectively blocked the AMPK phosphorylation