Camden et al., J Biol Chem 2005
(MAP Kinase Signaling System) :
U0126, an inhibitor of the mitogen activated protein kinase pathway, partially inhibited sAPPalpha release by UTP, whereas inhibitors of Src dependent epidermal growth factor receptor transactivation by P2Y2Rs had no effect
Boucher et al., Exp Eye Res 2007
:
These studies indicate that injury induced purinergic receptor activation leads to phosphorylation of EGFR , ERK and migration
Ratchford et al., J Biol Chem 2010
:
P2Y2 nucleotide receptors mediate metalloprotease dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells ... The EGFR dependent stimulation of UTP induced ERK1/2 phosphorylation in HSG cells is inhibited by the adamalysin inhibitor tumor necrosis factor-alpha protease inhibitor or by small interfering RNA that selectively silences ADAM10 and ADAM17 expression, suggesting that ADAM metalloproteases are required for P2Y(2)R mediated activation of the EGFR