◀ Back to EPHB2
EPHB2 — MMP2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
da Rocha et al., Pathobiology 2000
(Glioma...) :
Inhibition of ODC activity ( about 2-fold by 24 h DFMO 5 mM ),
ERK activation ( almost completely by 20 min PD 098059 50 microM ), or both these enzymes simultaneously
led to a reduction by about half in levels of MT1-MMP mRNA, 59/62-kD
MMP-2 activity, and invasion in untreated as well as PMA stimulated cells
Shearer et al., Invest Ophthalmol Vis Sci 2002
:
Cells were treated with CHA, and the secretion of
matrix metalloproteinase (MMP)-2 or the
activation of extracellular signal regulated kinase (
ERK1/2 ) was determined
Ruhul Amin et al., Cancer Res 2003
(MAP Kinase Signaling System) :
Taken together, our results strongly suggest that SHP-2 plays a critical role as a positive mediator for Con A-dependent
activation of
MMP-2 secretion via
Ras-Erk and Ras-p38 signalings
Sylvester et al., Cell Signal 2004
:
ERK pathway inhibitors, PD98059 and U0126,
down-regulated IL-17 induced
MMP and ADAM-TS4 gene expression
Shah et al., Mol Endocrinol 2004
:
Agonist mediated
MMP activation in C9 cells
led to shedding of heparin binding EGF (HB-EGF) and stimulation of
ERK1/2 phosphorylation
Ito et al., Cancer Res 2004
(MAP Kinase Signaling System...) :
These results suggest that PGE ( 2 ) mediates pancreatic cancer cellular invasiveness through an
ERK/Ets-1 dependent
induction of
MMP-2 expression and activity
Kim et al., Int J Oncol 2004
(Breast Neoplasms...) :
Using chemical inhibitors and dominant negative mutants of MAPKs, we provide evidence that while both p38 MAPK and ERKs are required for TGF-beta induced MCF10A cell migration and invasion, TGF-beta induced
MMP-2 and MMP-9 expression depends on p38 MAPK signaling, but is
independent of
ERK activity
Purdom et al., J Pharmacol Exp Ther 2005
:
In HFs,
MMP inhibitors GM6001 [ N- [ ( 2R ) -2- ( hydroxamidocarbonylmethyl ) -4-methylpentanoyl ] -l-tryptophan methylamide ] and BB2516 [ [ 2S- [ N4 ( R ( * ) ) ,2R ( * ) ,3S ( * ) ] ] -N4- [ 2,2-dimethyl-1- [ ( methylamino ) carbonyl ] propyl ] -N1,2-dihydroxy-3- ( 2-methylpropyl ) butanediamide, marimastat ]
inhibited JNKs and
ERK1/2 activation without affecting p38 activation by H ( 2 ) O ( 2 ) inhibitors
Ko et al., Mol Cancer Ther 2005
(Carcinoma...) :
ERK inhibitor ( PD98059 ) and PKC inhibitors ( GF-109203X and H-7 ), but not p38 inhibitor ( SB203580 ) or c-jun-NH2-kinase inhibitor ( SP600125 ), significantly
inhibited TPA induced
MMP-2 protein expression, with reduced ERK phosphorylation and c-Jun protein expression
Spallarossa et al., Cardiovasc Res 2006
(MAP Kinase Signaling System) :
To investigate the signaling pathways leading to doxorubicin induced MMP activation, we also examined the phosphorylation of three members of the MAPK family ( ERK1/2, p38, and JNK ), the
effects of selective inhibitors of
ERK1/2 , p38, and JNK on
MMP transcription and activity, the transcription of the NAD ( P ) H oxidase subunit Nox1, and the effects of the NAD ( P ) H oxidase inhibitor DPI on MMP activation
Shah et al., J Neurochem 2006
:
Phe induced phosphorylation of the EGF-R, and subsequently of Shc and
ERK1/2 , was
attenuated by inhibition of
MMP or HB-EGF with the selective inhibitor, CRM197, or by a neutralizing antibody ... In contrast, phosphorylation of the EGF-R, Shc and
ERK1/2 by EGF and HB-EGF was
independent of PKC and
MMP activity
Yang et al., J Pharmacol Exp Ther 2006
(Stomach Ulcer) :
rCRAMP also increased EGFR and
ERK1/2 phosphorylation via an
MMP dependent mechanism
Aitken et al., Am J Pathol 2006
(Mechanotransduction, Cellular) :
Similarly, stretching BSMCs in vitro induced increases in ERK1/2 activation and ERK1/2 dependent proliferation under discrete mechanical conditions, and distension conditioned medium itself induced
MMP dependent
ERK1/2 activation in BSMCs. Overall, stretch induced proliferation and ERK1/2 signaling in bladder tissue and BSMCs likely depend on secreted MMP activity
Meriane et al., Stem Cells 2006
(MAP Kinase Signaling System) :
Moreover,
MMP- and ROCK dependent molecular events are implicated in the
regulation of the S1P induced activation of
ERK
Hsieh et al., Carcinogenesis 2007
(Bone Neoplasms...) :
Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the
ERK dependent c-Jun/AP-1 induction of
MMP-2
Tellier et al., Mol Cell Biol 2007
:
Pharmacological and molecular inhibitors of MMPs ( batimastat ), furin ( alpha1-PDX inhibitor transfected SMC ), MT1-MMP ( SMC overexpressing a catalytically inactive MT1-MMP ),
MMP2 ( fibroblasts from MMP2 ( -/- ) mice ), and small interfering RNA ( siRNA ) strategies ( siRNAs targeting furin, MT1-MMP, MMP2, and nSMase )
resulted in near-complete inhibition of the activation of nSMase, sphingosine kinase-1, and
ERK1/2 and of subsequent DNA synthesis
Mendes et al., Clin Exp Metastasis 2007
(Brain Neoplasms...) :
Furthermore, our results suggest that astrocyte factors and the ERK1/2 signaling pathway may be associated with BC brain metastasis development ; and that
ERK1/2 may
regulate MMP2 in a way that is modifiable by astrocyte factors
Kim et al., FEBS Lett 2007
(Fibrosarcoma...) :
Pro-MMP-2 activation by the PPARgamma agonist, ciglitazone,
induces cell invasion through the generation of ROS and the activation of
ERK ... This study suggests that ciglitazone induced
pro-MMP-2 activation
increases PPARgamma independent tumor cell invasion through ROS production and
ERK activation in some types of cancer cells
Prast et al., Endocrinology 2008
:
Inhibition of
ERK or AKT
diminished CG-induced
MMP-2 expression
Chetty et al., Cancer Res 2008
(Lung Neoplasms...) :
Overexpression of constitutively active AKT reversed the
Ad-MMP-2-Si-CM mediated inhibition of tube formation and induction of
ERK phosphorylation
Lin et al., J Biol Chem 2008
:
This study provides the first evidence that
MMP mediated cleavage of
EphB2 is induced by receptor-ligand interactions at the cell surface and that this event triggers cell-repulsive responses
Fromigué et al., J Biol Chem 2008
(MAP Kinase Signaling System...) :
Inhibition of JNK, but not
ERK1/2 signaling,
reduced MMP2 activity
Cheng et al., Mol Cell Biochem 2009
:
After administration of inhibitors including U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ), SP600125 ( JNK1/2 inhibitor ), CsA ( calcineurin inhibitor ), and QNZ ( NFkappaB inhibitor ), the LPS upregulated expression and/or activity of uPA,
MMP-2 , and MMP-9 in H9c2 cardiomyoblasts are markedly
inhibited only by
ERK1/2 inhibitors, U0126
Xie et al., Am J Physiol Gastrointest Liver Physiol 2009
(Colonic Neoplasms) :
ACh induced MMP1,
MMP7 , and MMP10 gene transcription was
attenuated by atropine, anti-EGFR antibody, and chemical inhibitors of EGFR and
ERK activation
Shih et al., J Agric Food Chem 2009
(Adenocarcinoma...) :
Furthermore, the
ERK inhibitor ( U0126 ) could
result in reduced activities of
MMP-2 and u-PA concomitantly with a marked inhibition on cell invasion and migration
Chang et al., Evidence-based complementary and alternative medicine : eCAM 2011
:
Schwann Cell Migration Induced by Earthworm Extract via
Activation of PAs and
MMP2/9 Mediated through
ERK1/2 and p38
Pan et al., Zhonghua Kou Qiang Yi Xue Za Zhi 2010
:
To investigate the effect of ERK signaling pathway and MMP-9 on migration of hPDLC, the cells were incubated with PD98059, a specific extracellular signal regulated kinase (
ERK ) kinase inhibitor, or doxycycline, a
MMP inhibitor
Li et al., Phytomedicine 2010
(Hyperplasia) :
However, HG-down regulated MT-1
MMP expression was
independent of activation of
ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Ta et al., Atherosclerosis 2010
:
Taken together, this study showed for the first time that the inhibition of DPP-4/CD26 by alogliptin suppressed TLR4 mediated ERK activation and
ERK dependent
MMP expression by U937 cells, suggesting that DPP-4/CD26 may play an important role in macrophage mediated inflammation response and tissue remodeling
Liu et al., J Formos Med Assoc 2010
(Carcinoma, Squamous Cell...) :
Both SBT and LBT upregulate
MMP-2 expression, and LBT induced MMP-2 expression might be
mediated by phosphoinositide 3-kinase, p38 mitogen activated protein kinase, c-Jun N-terminal kinase, and nuclear factor-?B, and to a lesser extent, by reactive oxygen species, rather than by
ERK
Du et al., Hum Reprod 2012
:
CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase (
MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely
inhibited the CsA induced increase in cell number, invasion and MMP-9 and
MMP-2 activity of cytotrophoblast
Mou et al., J Biol Chem 2013
(Brain Neoplasms...) :
We further demonstrated that hHK-1 boosted rapid phosphorylation of ERK, JNK, and Akt ; inhibition of
ERK and Akt effectively
reduced MMP-2 induction by hHK-1
Lee et al., J Biol Chem 2013
(Neoplasm Invasiveness...) :
Blockade of p21 ( WAF1 ) function by siRNA reversed migration, invasion,
activation of
ERK signaling,
MMP-9 expression, and activation of NF-?B in IL-20 treated cells
Dong et al., Am J Pathol 2013
(Carcinoma, Non-Small-Cell Lung...) :
Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via
EGFR-ERK mediated up-regulation of
MMP-2 and MMP-9 ... In summary, our results showed that Derlin-1 is overexpressed in NSCLC and promotes invasion by
EGFR-ERK mediated up-regulation of
MMP-2 and MMP-9
Sun et al., Mol Cell Biochem 2013
(Calcium Signaling...) :
Intracellular calcium chelator BAPTA-AM, the selective inhibitor of EGFR AG1478 and the selective inhibitor of
Erk PD98059
blocked EP1 receptor activation induced CREB phosphorylation and
MMP2 expression
Deng et al., BMC complementary and alternative medicine 2013
(Colorectal Neoplasms...) :
These findings demonstrate that YQFS extract has an anti-tumor effect in colorectal cancer, which could be attributed to
ERK1/2 dependent inhibition of
MMP-2/9 expression
Wu et al., BMC cancer 2013
:
Our study indicates that GnRH-II agonist promoted cell motility of endometrial cancer cells through the GnRH-I receptor via the phosphorylation of
ERK1/2 and JNK, and the subsequent, MAPK dependent
activation of
MMP-2