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HDAC3 — MYC

Pathways - manually collected, often from reviews:

• NCI Pathway Database Validated targets of C-MYC transcriptional repression: HDAC3 (HDAC3) → MYC/Max/HDAC3 complex (MYC-MAX-HDAC3) (modification, collaborate)
  Kurland et al., Cancer Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional repression: HDAC3 (HDAC3) → MYC/Max complex (MYC-MAX) (modification, collaborate) Kurland et al., Cancer Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional repression: MYC/Max/HDAC3 complex (MYC-MAX-HDAC3) → MYC/Max complex (MYC-MAX) (modification, collaborate) Kurland et al., Cancer Res 2008
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional repression: MYC/Max/HDAC3 complex (MYC-MAX-HDAC3) → MYC/Max/MIZ-1 complex (MYC-MAX-ZBTB17) (transcription, inhibits)
  Barsyte-Lovejoy et al., Oncogene 2004, Kurland et al., Cancer Res 2008
  Evidence: mutant phenotype, reporter gene, physical interaction
• NCI Pathway Database Validated targets of C-MYC transcriptional repression: MYC/Max/HDAC3 complex (MYC-MAX-HDAC3) → CHOP (DDIT3) (transcription, inhibits) Barsyte-Lovejoy et al., Oncogene 2004, Kurland et al., Cancer Res 2008
  Evidence: mutant phenotype, reporter gene, physical interaction

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: HDAC3 — MYC (physical association, affinity chromatography technology) Kurland et al., Cancer Res 2008
• IRef Biogrid Interaction: HDAC3 — MYC (physical association, affinity chromatography technology) Zhang et al., Oncogene 2012*
• IRef Intact Interaction: MYC — HDAC3 (association, anti bait coimmunoprecipitation) Zhang et al., Cancer Cell 2012*
• IRef Intact Interaction: Complex of MYC-HDAC3-SUZ12-HDAC3-SUZ12-MYC (association, anti bait coimmunoprecipitation) Zhang et al., Cancer Cell 2012*
• IRef Intact Interaction: Complex of EZH2-HDAC3-MYC-SUZ12-EZH2-HDAC3-MYC-SUZ12 (association, anti bait coimmunoprecipitation) Zhang et al., Cancer Cell 2012*

Text-mined interactions from Literome

Kadeppagari et al., J Virol 2009 (Cell Transformation, Viral) : We demonstrated that p300 and HDAC3 cooperate with the transcription factor YY1 at an upstream YY1 binding site and repress the Myc promoter
Zhang et al., Oncogene 2012 (Lymphoma, Non-Hodgkin) : Moreover, using chromatin immunoprecipitation, we demonstrated that both c-Myc and HDAC3 co-localized to the two promoters of the miR-15a/16-1 cluster gene, DLEU2, and inhibition of HDAC3 increased histone acetylation of the DLEU2 promoters