Densham et al., Mol Cell Biol 2009
:
The expression of MST1 or MST2 was sufficient to stabilize p21 in a JNK- and Thr57 dependent manner, while the stabilization of p21 by actin disruption required MST activity
Serrano et al., Molecular cancer 2011
(Carcinoma, Non-Small-Cell Lung...) :
Interestingly, MST312 has a strong antiproliferative effect on lung CSCs and induces p21 , p27 and apoptosis in the whole tumor population