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PPARA — PTGS2

Text-mined interactions from Literome

Bonazzi et al., J Biol Chem 2000 : The PPAR activator, WY-14,643 increased COX-2 expression ... This study also suggests that increased cellular GSH may be the mechanism responsible for the characteristic dissociation of PPAR induced COX-2 expression and activity
Kalajdzic et al., Arthritis Rheum 2002 (Osteoarthritis) : PPARalpha and, especially, PPARgamma mediated the induction of COX-2 gene expression by receptor agonists ... PPAR mediated induction of COX-2 expression and synthesis in human OA synovial fibroblasts is inhibited by therapeutic concentrations of NIM through the functional antagonism of ligand dependent receptor activation, with the resultant suppression of PPAR dependent transactivation of target genes ( e.g., COX-2 )
Yu et al., Hepatology 2006 (Choline Deficiency...) : PPAR-alpha suppresses both COX-2 and development of steatohepatitis, while pharmacological inhibition of COX-2 activity ameliorates the severity of experimental steatohepatitis
Sheldrick et al., Biochem J 2007 : Use of agonists and antagonists indicated PPARalpha ( but not PPARdelta or PPARgamma ) was responsible for PTGS2 induction
Taketa et al., J Biol Chem 2008 (Atherosclerosis...) : Ox-LDL transiently induced cyclooxygenase-2 (COX-2) mRNA and protein expression, and COX-2 specific inhibition by NS-398 or meloxicam or small interference RNA of COX-2 suppressed Ox-LDL induced PPARalpha and PPARgamma activation
Derecka et al., Mol Cell Endocrinol 2008 : PPAR independent reporter gene expression occurred 6h after PPAR dependent induction of the endogenous COX-2 gene ... In contrast to PPAR dependent COX-2 induction, which is not affected by NF-kappaB inhibitors, the PPAR independent pathway was blocked by the NF-kappaB inhibitor MG132 or following deletion of NF-kappaB sites in the COX-2 promoter
Katsukawa et al., Biochim Biophys Acta 2010 : We found that COX-2 promoter activity was suppressed by lemongrass oil in cell based transfection assays, and we identified citral as a major component in the suppression of COX-2 expression and as an activator of PPARa and ?. PPAR? dependent suppression of COX-2 promoter activity was observed in response to citral treatment
Du et al., Br J Pharmacol 2011 (Inflammation...) : The purpose of the present study was to determine whether PPAR? , an important nuclear receptor, mediates 2-AG induced inhibition of NF-?B phosphorylation and COX-2 expression, and COX-2 enhanced miniature spontaneous excitatory postsynaptic currents ( mEPSCs )
Martín et al., J Hypertens 2012 : PPAR? activation with pioglitazone reduces interleukin-1ß induced COX-2 expression by interference with the redox-sensitive transcription factor NF-?B
Kogiso et al., Inflammation 2012 (Pneumonia) : Role of PPAR? in COX-2 activation in mycobacterial pulmonary inflammation ... Our results indicate that PPAR? upregulates M1 activation of alveolar Mf, but inactive COX-2 formation is independent of PPAR? in mycobacterial pulmonary inflammation
Díaz-Gandarilla et al., BioMed research international 2013 (Leishmaniasis, Diffuse Cutaneous) : PPAR Activation Induces M1 Macrophage Polarization via cPLA 2 -COX-2 Inhibition, Activating ROS Production against Leishmania mexicana
Staels et al., Nature 1998 (Coronary Disease...) : In these smooth-muscle cells, we find that PPARalpha ligands, and not PPARgamma ligands, inhibit interleukin-1 induced production of interleukin-6 and prostaglandin and expression of cyclooxygenase-2 ... This inhibition of cyclooxygenase-2 induction occurs transcriptionally as a result of PPARalpha repression of NF-kappaB signalling