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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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CCL2 — LEP

Text-mined interactions from Literome

Yamagishi et al., J Biol Chem 2001 : Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A ... In this study, we investigated the effects of leptin on reactive oxygen species ( ROS ) generation and expression of monocyte chemoattractant protein-1 ( MCP-1 ) in bovine aortic endothelial cells ( BAEC )
Fukuda et al., Fertil Steril 2003 : The effects of leptin on the production of IL-6, IL-11, leukemia inhibitory factor (LIF), IL-8, growth regulated oncogene ( GRO ) -alpha, monocyte chemoattractant protein (MCP)-1 , and macrophage inflammatory protein (MIP)-3alpha by ESC and the endometrial epithelial cell line HHUA were investigated
Piñieiro et al., Endocr Res 2005 : Leptin does not induce hypertrophy, cell cycle alterations, or production of MCP-1 in cultured rat and mouse cardiomyocytes ... To investigate whether leptin causes hypertrophy or cell cycle alterations, or induces MCP-1 synthesis in cardiomyocytes
Peeraully et al., Pflugers Arch 2006 : Prostaglandin D2 and J2-series ( PGJ2, Delta12-PGJ2 ) prostaglandins stimulate IL-6 and MCP-1 , but inhibit leptin , expression and secretion by 3T3-L1 adipocytes
Madan et al., Cytokine 2009 (Inflammation...) : Maternal obesity in pregnancy is associated with changes in cytokines, protein hormones and acute phase proteins in the second trimester, with an increase in MCP-1 in the morbid obesity category, and an increase in Leptin and hsCRP with increasing BMI category
Allman et al., Mediators Inflamm 2009 (Inflammation) : Compared to vehicle controls, leptin enhanced mRNA levels of IL-6 ( 8-fold ) and MCP-1 ( 5-fold ) in mesenteric adipose tissue ( MAT )
Ryan et al., Pflugers Arch 2010 : The PPARgamma agonist rosiglitazone stimulated both adiponectin and leptin expression and inhibited the expression of IL-6, MCP-1 and TNFalpha ; MCP-1 secretion was reduced
Zhou et al., Nutrition & metabolism 2012 : Leptin also up-regulated MCP-1 secretion in a dose- and time dependent manner