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CD163 — IL10
Text-mined interactions from Literome
Ritter et al., Pathobiology 1999
:
Because an important function of CD163 in inflammation has been suggested, we investigated the influence of pro- and anti-inflammatory stimuli on CD163 expression and found a significant suppression by lipoposaccharide and IFN-gamma, whereas
IL-10 or dexamethasone strongly
induced the expression of
CD163
Sulahian et al., Cytokine 2000
:
We also show that
IL-10 , like glucocorticoids,
induces high
CD163 expression on cultured human monocytes ... Glucocorticoid induced
CD163 expression was not
inhibited by
anti-IL-10 and was additive with IL-10 treatment, suggesting that glucocorticoids increase CD163 expression by an IL-10 independent mechanism
Graversen et al., Int J Biochem Cell Biol 2002
:
The
CD163 expression is
induced by interleukin-6,
interleukin-10 and glucocorticoids ... The
CD163 expression is
induced by interleukin-6,
interleukin-10 and glucocorticoids
Philippidis et al., Circ Res 2004
(Blister...) :
Hemoglobin scavenger receptor
CD163 mediates
interleukin-10 release and heme oxygenase-1 synthesis : antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery
Pioli et al., J Leukoc Biol 2004
:
CD163 surface expression is
up-regulated by glucocorticoids and the anti-inflammatory cytokine
interleukin-10 , and CD163 is shed acutely from the cell surface in response to lipopolysaccharide
Ambarus et al., J Immunol Methods 2012
:
IFN-? polarized macrophages ( MF ( IFN-? ) ) specifically enhanced membrane expression of CD80 and CD64, IL-4 polarized macrophages ( MF ( IL-4 ) ) mainly upregulated CD200R and CD206, and downregulated CD14 levels, and
IL-10 polarized macrophages ( MF ( IL-10 ) ) selectively
induced CD163 , CD16, and CD32
Moura et al., Eur J Immunol 2012
(Leprosy, Lepromatous) :
The regulatory phenotype in ML-stimulated monocytes was accompanied by increased TNF, IL-10, and TGF-ß levels whereas
IL-10 blockade
reduced ML-induced
CD163 expression
Franzè et al., PloS one 2013
:
Functionally,
interleukin-6 up-regulated
CD163 expression in lamina propria mononuclear cells and mucosal explants of normal subjects