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PAK1 — PLCG1

Pathways - manually collected, often from reviews:

• Reactome Reaction: PAK1 → PLCG1 (reaction) Chong et al., J Biol Chem 2001, Parrini et al., Mol Cell 2002, Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999
• Reactome Reaction: PAK1 → PLCG1 (indirect_complex) Zhao et al., Biochem J 2005, Allen et al., Blood 2009, Parrini et al., J Biol Chem 2009, Lu et al., Oncogene 1999

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PAK1 — PLCG1 (direct interaction, pull down) Shin et al., Exp Mol Med 2002*
• IRef Hprd Interaction: PAK1 — PLCG1 (in vitro) Shin et al., Exp Mol Med 2002*
• IRef Hprd Interaction: PAK1 — PLCG1 (in vivo) Shin et al., Exp Mol Med 2002*
• IRef Ophid Interaction: PAK1 — PLCG1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Shin et al., Exp Mol Med 2002 : Phospholipase C-gamma1 ( PLC-gamma1 ) can mediate the PAK translocation in response to growth factors, since PLC-gamma1 binds to both tyrosine phosphorylated receptor tyrosine kinases and PAK through its SH2 and SH3 domain, respectively ... In the present study, we examined a potential role for PLC-gamma1 in the basic fibroblast growth factor (bFGF) induced PAK translocation using stable PC12 cell lines that overexpress in a tetracycline-inducible manner either the wild-type FGFR-1 or the Y766F FGFR-1 mutant
Rouquette-Jazdanian et al., Mol Cell 2012 (MAP Kinase Signaling System) : The PLC-?1 ( SH3 ) -Pak1 interaction activates Pak1 independently of the small GTPases Rac1/Cdc42, previously described as being the only activators of Pak1 in T cells