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CCL3 — CCR1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CCR1 → CCL3 (increases, CCL3 Activity)
  Evidence: The identification of the heptahelical receptors CXCR1 and CXCR2 for IL-8 and its homologues [14, 15], as well as CCR1 and CCR2 for the CC chemokines MIP-1?/regulated on activation normal T cell expressed and secreted (RANTES; CC ligand 5) and monocyte chemotactic protein (MCP) 1 [16, 17],
• OpenBEL Selventa BEL large corpus: CCR1 → CCL3 (increases, CCL3 Activity)
  Evidence: Table 1. Lymphoid chemokine receptors
• OpenBEL Selventa BEL large corpus: CCR1 → CCL3 (directlyIncreases, CCL3 Activity)
  Evidence: MIP1alpha is released by macrophages and has chemotactic activity for monocytes and neutrophils via CCR1.
• KEGG Chemokine signaling pathway: CCL1/CCL11/CCL13/CCL14/CCL15/CCL16/CCL17/CCL18/CCL19/CCL2/CCL20/CCL21/CCL22/CCL23/CCL24/CCL25/CCL26/CCL27/CCL28/CCL3/CCL3L1/CCL3L3/CCL4/CCL4L1/CCL4L2/CCL5/CCL7/CCL8/CX3CL1/CXCL1/CXCL10/CXCL11/CXCL12/CXCL13/CXCL14/CXCL16/CXCL2/CXCL3/CXCL5/CXCL6/CXCL9/IL8/PF4/PF4V1/PPBP/XCL1/XCL2 → CCR1/CCR10/CCR2/CCR3/CCR4/CCR5/CCR6/CCR7/CCR8/CCR9/CX3CR1/CXCR1/CXCR2/CXCR3/CXCR4/CXCR5/CXCR6/XCR1 (protein-protein, activation)
  
• WikiPathways Chemokine signaling pathway: CCL19/CCL27/CXCL3/CXCL10/XCL1/CXCL9/CCL21/CCL1/CCL11/CCL7/CCL17/CCL20/CCL22/CCL25/CCL27/CCL3/CCL4/CCL5/CCL15/CCL7/CCL15/CXCL3/CXCL5/CX3CL1/CXCL12/CCL19/CCL26/CXCL13/CXCL11/CCL24/PF4/CCL28/CXCL14/PPBP/CCL21/CXCL16 → CXCR5/CCR6/CXCR2/CXCR3/CXCR4/CCR1/CCR9/CCR1/CCR3/CCR2/CCR4/CCR2/CCR7/CCR8/CCR10/CX3CR1/CXCR2/XCR1/CXCR6 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Dip Interaction: CCR1 — CCL3 (physical association, biochemical) Ben-Baruch et al., J Biol Chem 1995*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Combadiere et al., J Biol Chem 1995*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Youn et al., Blood 1999*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, biochemical) Combadiere et al., J Biol Chem 1995*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Baba et al., J Biol Chem 1997*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, biochemical) Gong et al., J Biol Chem 1997*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Kitaura et al., J Biol Chem 1999*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Tiffany et al., J Exp Med 1997*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, experimental interaction detection) Tsou et al., J Exp Med 1998*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, biochemical) Howard et al., Blood 2000*
• IRef Dip Interaction: CCR1 — CCL3 (physical association, biochemical) Sarau et al., J Pharmacol Exp Ther 1997*
• IRef Hprd Interaction: CCR1 — CCL3 (in vivo) Zhang et al., J Immunol 1999*, Berkhout et al., Biochem Pharmacol 2000*, Ben-Baruch et al., J Biol Chem 1995*
• IRef Hprd Interaction: CCR1 — CCL3 (in vitro) Zhang et al., J Immunol 1999*, Berkhout et al., Biochem Pharmacol 2000*, Ben-Baruch et al., J Biol Chem 1995*
• IRef Innatedb Interaction: CCR1 — CCL3 (unknown, -) Gong et al., J Biol Chem 1997*
• IRef Innatedb Interaction: CCR1 — CCL3 (unknown, -) Combadiere et al., J Biol Chem 1995*
• IRef Innatedb Interaction: CCR1 — CCL3 (unknown, -) Chou et al., Br J Pharmacol 2002*
• IRef Innatedb Interaction: CCR1 — CCL3 (unknown, -) Ben-Baruch et al., J Biol Chem 1995*
• IRef Ophid Interaction: CCR1 — CCL3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• IRef Ophid Interaction: CCR1 — CCL3 (aggregation, confirmational text mining) Berkhout et al., Biochem Pharmacol 2000*

Text-mined interactions from Literome

Kaufmann et al., J Leukoc Biol 2001 : Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages
Parker et al., J Immunol 2004 (MAP Kinase Signaling System) : Enhanced macrophage-inflammatory protein 1 alpha production may contribute to the prolonged down-regulation of CCR1 cell surface expression observed in response to the TLR2 agonist, as preventing chemokine generation with the protein synthesis inhibitor cycloheximide, or CCR1 signaling with the receptor antagonist UCB35625, abolished TLR2- and TLR4 induced CCR1 down-modulation
Corbin et al., J Neurovirol 2006 (Nervous System Diseases...) : Additionally, CCR1 deficiency did not affect the up-regulation of its ligands, CCL3 , CCL5, or CCL7
Wong et al., J Biol Chem 1998 : RANTES and MIP-1alpha mediate their effects via shared chemokine receptors ( CCRs ) : CCR1 , CCR4, and CCR5