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Text-mined interactions from Literome

Singh et al., Atherosclerosis 2011 (Atherosclerosis) : Leptin upregulates caveolin-1 expression : implications for development of atherosclerosis ... Dose dependent effect of leptin on caveolin-1 expression was determined by Western blot analysis ... Leptin upregulates caveolin-1 protein expression in a dose dependent manner and increased caveolin-1 expression impairs leptin signaling ... Leptin increases caveolin-1 protein expression which impairs leptin signaling in vascular endothelial cells
Singh et al., Circ Res 2012 (Hyperphagia...) : Increases in leptin have been shown to impair leptin signaling via caveolin-1 dependent mechanisms ... To determine the presence and significance of leptin dependent increases in adipose tissue caveolin-1 expression in humans ... We designed a longitudinal study to investigate the effects of increases in leptin on adipose tissue caveolin-1 expression during weight gain in humans ... In cultured human white preadipocytes, leptin increased caveolin-1 expression, which in turn impaired leptin cellular signaling ... In healthy humans, increases in leptin , as seen with modest weight gain, may increase caveolin-1 expression in adipose tissue