◀ Back to PTGS2

PTGS2 — S100B

Text-mined interactions from Literome

Shanmugam et al., J Biol Chem 2003 : In this study, we investigated the effect of AGEs and S100b , a specific RAGE ligand, on the expression of COX-2 and the molecular mechanisms involved in cultured THP-1 monocytes and human peripheral blood monocytes ... S100b also increased COX-2 mRNA expression in human peripheral blood monocytes from healthy donors
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We show here that : ( 1 ) S100B also stimulates AP-1 transcriptional activity in microglia via RAGE dependent activation of JNK ; ( 2 ) S100B upregulates IL-1beta and TNF-alpha expression in microglia via RAGE engagement ; and ( 3 ) S100B/RAGE induced upregulation of COX-2 , IL-1beta and TNF-alpha expression requires the concurrent activation of NF-kappaB and AP-1
Shanmugam et al., J Biol Chem 2008 : S100b treatment promoted the translocation of nuclear hnRNPK to cytoplasm, whereas a cytoplasmic translocation-deficient hnRNPK mutant inhibited S100b induced COX-2 mRNA stability ... Small interfering RNA mediated specific knockdown of hnRNPK blocked S100b induced COX-2 mRNA stability, whereas on the other hand, overexpression of hnRNPK increased S100b induced COX-2 mRNA stability