Yan et al., J Mol Biol 2006
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We have further provided evidence that the DOCK4-Ex49 binds to nucleotide free Rac as effectively as DOCK2 and DOCK4 and it is a potent Rac activator
Upadhyay et al., Oncogene 2008
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We report that DOCK4 , a guanine nucleotide exchange factor (GEF) for Rac and a member of the CDM family of unconventional GEFs, mediates Wnt induced Rac activation in the canonical Wnt/beta-catenin pathway
Namekata et al., Proc Natl Acad Sci U S A 2010
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BDNF induces axonal sprouting through Dock dependent Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
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Multiple factors confer specific Cdc42 and Rac protein activation by dedicator of cytokinesis ( DOCK ) nucleotide exchange factors